摘要
Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease with an estimated global prevalence of 25%.Approximately 5%of NAFLD patients have cirrhosis and currently NAFLD is the second most common etiology among adults awaiting liver transplant in the United States.In the Western world alcohol overconsumption is the leading cause for advanced decompensated liver disease but whether moderate alcohol consumption,compatible with the diagnosis of NAFLD,plays a role for development of liver-related complications in NAFLD is disputed.Although NAFLD entails a clinically significant risk for encountering complications of advanced liver disease,cardiovascular disease(CVD)is the leading cause of mortality and morbidity among subjects with NAFLD.NAFLD and CVD share many common risk factors,for instance components of the metabolic syndrome.It has been reported that modest alcohol consumption is associated with beneficial effects on risk of metabolic syndrome and insulin resistance,which are crucial for the development and progression of NAFLD.
