摘要
目的:探讨呋喃西林溶液湿敷对西妥昔单抗联合化疗所致恶性肿瘤患者皮肤反应的临床疗效。方法:将108例西妥昔单抗联合化疗的肿瘤患者,随机分为两组(干预组58例、对照组50例),对照组给予常规护理,干预组应用呋喃西林溶液局部湿敷,每日早晚各1次,静脉输注西妥昔单抗药物后3d内每日中午加敷1次,观察5d、10d两组皮疹变化。结果:给予治疗后两组患者皮疹的消退时间差异有统计学意义(P<0.05),干预组5d后显效率达89.6%,10d后痊愈34.4%,显效达65.6%,皮疹消退与痒感明显好于对照组。结论:呋喃西林溶液湿敷治疗西妥昔单所致的皮肤不良反应,疗效确切,安全经济,操作简便,值得临床应用。
Objective:To evaluate the efficacy of wet compress with Furacilin Solution for cetuximab related erythra in patients with malignant tumor.Methods:108 patients with treatment of cetuximab combined with chemotherapy were randomly divided into two groups.The 50 patients in experimental group received normal treatment.The 58 patients in experimental group received wet compress with Furacilin Solution twice per day.Within the initial three days in using cetuximab Furacilin Solution was administrated three times per day.The efifcacy was observed on the 5th day and the 10th day.Results:The efifcacy of two groups was statisticaly different(P<0.05).5 days and 10days after the treatment,the effective rate of experimental group was 89.6%and 65.6%separately.After 10 days,20 patients(34.4%)were completely recovered.The efifcacy of experimental group was signiifcantly better than control group.Conclusion:Wet compress with Furacilin Solution are safe,effective,economical and feasible for cetuximab related erythra,which are valuable to be applied in practice.
作者
郭洪霞
穆婷婷
董成名
马海娟
GUO Hong-xia;MU Ting-ting;DONG Cheng-ming;MA Hai-juan(Department of Internal Medicine-Breath China PLA General Hospital,Beijing 100853,China)
出处
《临床药物治疗杂志》
2014年第S01期32-34,共3页
Clinical Medication Journal
