摘要
目的探讨寻常型天疱疮(pemphigus vulgaris,PV)与甲状腺疾病之间的相关性。方法通过回顾性分析107例完善甲状腺功能检测的PV患者作为研究对象,以同时期新疆维吾尔自治区人民医院250例健康体检人群作为对照组,统计及比较血清中三碘甲状腺原氨酸(T3)、甲状腺素(T4)、血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、血清促甲状腺激素(TSH)、抗甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPO-Ab)的表达水平。按年龄、性别、病情严重程度等分层进行比较甲状腺疾病患病率及甲状腺指标表达水平。结果①PV组与对照组甲状腺功能对比,T3、T4、FT3、FT4、TSH水平低于对照组,差异有统计学意义(P<0.05)。②PV组与对照组患甲状腺疾病的对比,患亚临床甲亢、低T3综合征、自身免疫性甲状腺炎的比例高于对照组,差异有统计学意义(P<0.05)。③PV组中病情严重程度为重度患者的T3、FT3、TSH水平低于中度组,差异有统计学意义(P<0.05)。④PV患者中,随着病情严重程度的增加,桥粒核心糖蛋白(dsg)1、dsg3水平随之升高,但与甲状腺疾病患病率及甲状腺自身抗体表达水平无关。结论甲状腺功能异常、甲状腺疾病患病率在PV患者中更容易发生,在诊断及随访中需常规行甲状腺功能检查,重视甲状腺疾病的诊断及治疗。
Objective To investigate the relationship between pemphigus vulgaris(PV)and thyroid diseases.Methods 107 patients diagnosed with PV,and 250 healthy individuals were included in this retrospective study.Serum samples were collected from these groups to determine and compare the expression levels of triiodothyronine(T3),thyroxine(T4),free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulatinghormone(TSH),anti-thyroglobulin antibody(TGAb)and anti-thyroid peroxidase antibody(TPO-Ab).The prevalence of thyroid diseases and the expression level of thyroid indicators were compared according to age,sex and severity of illness.Results 1.Compared to the control group,the PV group exhibited signifi cantly lower levels of T3,T4,FT3,FT3 and TSH(P<0.05).2.Compared with the control group,the incidence of subclinical hyperthyroidism,low T3 syndrome and autoimmune thyroiditis in PV group was higher than that in control group,and the difference was statistically signifi cant(P<0.05).3.Patients with severe PV exhibited lower levels of T3,FT3 and TSH compared to those with moderate PV(P<0.05).4.In PV patients,with the increase of the severity of the disease,the levels of dsg1 and dsg3 increased,however,these levels were not associated with the prevalence of thyroid diseases or the expression level of thyroid autoantibodies.Conclusions The possibility of autoimmune thyroid disease(AITD)occurring in PV patients with positive thyroid autoantibodies is high.It is therefore necessary to examine thyroid function and thyroid autoantibodies in patients diagnosed with pemphigus during the initial diagnosis and follow-up.These examinations can detect the existence of thyroid diseases in their early stages thus enabling simultaneous treatmentof the two diseases.
作者
毛丽旦
梁俊琴
胡凤侠
王倩
康晓静
MAO Li-dan;LIANG Jun-qin;HU Feng-xia(Department of Dermatology and Venereology,People’s Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Clinical Research Center for Dermatologic Diseases,Xinjiang Key Laboratory of Dermatology Research(XJYS1707),Urumqi 830001,China)
出处
《实用皮肤病学杂志》
2023年第6期331-334,共4页
Journal of Practical Dermatology
基金
国家自然科学基金资助项目(81960564)
国家自然科学基金资助项目(82260621)
