摘要
目的:探讨不同剂量咪达唑仑静脉给药辅助腰硬联合麻醉在肛肠疾病手术中的应用效果。方法:选择2021年4月至2022年2月于我院接受手术治疗的80例肛肠疾病患者为研究对象,随机数字表法将其分为研究1组(26例)、研究2组(27例)和研究3组(27例),3组患者均于腰硬联合麻醉下进行肛肠手术,并应用不同剂量咪达唑仑静脉给药辅助麻醉,研究1组、研究2组、研究3组咪达唑仑剂量依次为0.05 mg/kg、0.10 mg/kg和0.15 mg/kg。比较3组整体麻醉效果,术前(T_(0))、麻醉后30 min(T_(1))、术毕(T_(2))患者心率(HR)、平均动脉压(MAP)及血氧饱和度(SpO_(2)),术后不良反应发生情况。结果:研究1组麻醉不全4例,研究3组麻醉过度4例。研究2组麻醉满意率(100%)高于研究1组(84.62%)和研究3组(85.19%),P<0.05。3组患者T_(0)、T_(1)、T_(2)时刻HR、MAP、SpO_(2)比较差异均无统计学意义(P>0.05);3组患者T_(1)、T_(2)时刻HR、MAP均低于T_(0)时刻(P<0.05),3组患者T_(0)、T_(1)、T_(2)时刻SpO_(2)无显著差异(P>0.05)。研究3组术后不良反应发生率高于研究1组和研究2组(P<0.05),研究1组与研究2组无明显差异(P>0.05)。结论:0.10 mg/kg咪达唑仑静脉给药辅助腰硬联合麻醉用于肛肠疾病手术患者麻醉效果更好,血流动力学稳定,且术后不良反应更少。
Objective To investigate the efficacy of different doses of midazolam intravenously assisting the associated spinal and epidural anesthesia(ASEA)amidst surgery for coloproctological disease.Methods Randomly divided 80 patients undergoing coloproctological disease surgery in authors’hospital(2021-04-2022-02)into three research groups:No.1 group(26 cases),No.2 group(27 cases),and No.3 group(27 cases),which received the ASEA for surgery,only,the doses of midazolam was respectively 0.05 mg/kg,0.10 mg/kg,and 0.15 mg/kg in No.1,No.2 and No.3 group;then,compared whole anesthesia efficacy;the HR,MAP and SpO_(2)before surgery(T_(0)),30 min after anesthesia(T_(1))and at the end of surgery(T_(2));as well as postoperative unward reaction incidence between the three groups.Results In No.1 group incomplete anesthesia was in 4 cases,in No.3 group 4 cases from overanesthesia;the anesthesia satisfactory degree(100%)in No.2 was higher than No.1(84.62%)and No.3(85.19%)(P<0.05);In HR,MAP and SpO_(2)at T_(0),T_(1)and T_(2)there was no statistical difference between the three groups(P>0.05);at T_(1)and T_(2)the HR and MAP of the three groups were lower than at T_(0)(P<0.05);in unward reactions incidence No.3 was higher than No.1 and No.2(P<0.05),but there was no significant difference between the No.1 and No.2(P>0.05).Conclusion In the 3 concentrations of midazolam,0.10 mg/kg has optimum assisting anesthesia effect,its hemodynamics is stable,and postoperative unward reaction also less.
作者
张明新
ZHANG Ming-xin(Dept.of Anesthesia,the Second Affiliated Hospital of Nanyang Medical College for Professional Training,Nanyang,Henan 473000)
出处
《中国肛肠病杂志》
2022年第11期15-17,共3页
Chinese Journal of Coloproctology
关键词
咪达唑仑
腰硬联合麻醉
肛肠疾病
手术
Midazolam
Associated spinal and epidural anesthesia
Coloproctological disease
Surgery
