摘要
S-腺苷-L-高半胱氨酸水解酶(SAHase)是目前唯一已知催化S-腺苷-L-高半胱氨酸(SAH)可逆水解成高半胱氨酸和腺苷的酶,SAH是所有依赖S-腺苷-L-甲硫氨酸(SAM)的生物甲基转移反应的产物。SAHase抑制剂可以通过抑制SAH的催化水解,反馈性抑制SAM介导的甲基化过程从而抑制病毒m RNA的复制转录。近年来,SAHase已成为药物设计的热门靶标,SAHase抑制剂已表现出抗病毒、免疫抑制、抗肿瘤、抗菌等多种药理活性,SAHase抑制剂也取得了较大的进展,本文就近年来报道的SAHase及其抑制剂进行综述。
S-adenosy-L-homocysteine hydrolase(SAHase)is the only known enzyme to catalyze the breakdown of S-adenosy-L-homocysteine to homocysteine and adenosine.S-adenosy-L-homocysteine(SAH)is the product of all S-adenosy-L-methionine(SAM)dependent biological transmethylations.SAHase inhibitors act on catalyze the breakdown of S-adenosylhomocysteine and then feedback inhibit the reaction of SAM dependent biological transmethylations to inhibit viral mRNA transcription.In recent years,SAHase has become one of the most popular targets for drug design,SAHase inhibitors have shown various pharmacological activities such as antiviral,immunosuppressive,antitumor,antibacterial activities,and great progress has been made in the research on SAHase inhibitors.The SAHase inhibitors reported in recent years were introduced in this article.
作者
吕玉彬
周香辉
程娃
谭相端
Lv Yubin;Zhou Xianghui;Cheng Wa;Tan Xiangduan(School of Pharmacy,Guilin Medical University,Guilin 541100,China)
出处
《广东化工》
CAS
2021年第2期74-78,共5页
Guangdong Chemical Industry
基金
国家自然科学基金(82060627)
广西自然科学基金(2018GXNSFAA281114)
