摘要
维生素D及其受体在人体不同区域有广泛表达,后者介导活性维生素D的所有分子功能,其基因多态性已被证实与多种发育障碍类疾病易感性相关。现对维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进行综述,以期为患儿临床早期预防、干预和治疗提供理论参考。
Vitamin D and its receptors(VDR)are widely expressed in various regions of human body.VDR mediates all molecular effects of active vitamin D,and its gene polymorphisms have been linked to a variety of neurodevelopmental disease.This article reviews the association of vitamin D and VDR gene polymorphisms with childhood neurodevelopmental disorders,providing theoretical reference for early prevention,intervention and treatment in children.
作者
李嘉
张延赤
LI Jia;ZHANG Yanchi(Department of Clinical Pharmacy,Changchun Sixth Hospital,Changchun,Jilin 130000,China)
出处
《中国儿童保健杂志》
CAS
CSCD
2023年第5期516-520,共5页
Chinese Journal of Child Health Care
基金
吉林省卫生健康委员会科技创新项目(2021LC110)
关键词
维生素D
维生素D受体
基因多态性
神经发育障碍
vitamin D
vitamin D receptor
gene polymorphisms
neurodevelopmental disorders
