摘要
目的研究上海市儿童血砷水平、影响因素以及与体格生长的关联,为预防和干预由砷暴露引起的健康问题提供参考。方法选取2013—2015年招募的具有血液样本、体格生长指标和人口基线数据的2263名上海市0~6岁儿童作为研究对象,使用电感耦合等离子体质串联谱仪(ICP-MS/MS)测定全血总砷水平,采用单因素线性回归和多重线性回归分析砷暴露与儿童体格生长的关联。结果上海市儿童血砷的中位数水平为1.57μg/L。女童血砷水平高于男童(1.67μg/L vs.1.47μg/L,Z=510794.50,P<0.05);主要照看人吸烟的儿童血砷水平高于未吸烟的儿童(1.83μg/L vs.1.52μg/L,Z=275783.00,P<0.05),经常摄入海水鱼和淡水鱼的儿童血砷水平高于偶尔摄入海水鱼者(1.69μg/L vs.1.34μg/L,Z=417778.00,P<0.05)和淡水鱼者(1.69μg/L vs.1.37μg/L,Z=443342.00,P<0.05)。调整父母身高、体重、家庭经济状况后,砷暴露水平与儿童年龄别身高Z评分(β=-0.08,95%CI:-0.12~-0.03,P<0.01)、年龄别体重Z评分(β=-0.07,95%CI:-0.11~-0.03,P<0.01)及年龄别BMI-Z评分(β=-0.05,95%CI:-0.10~0.00,P=0.03)均呈显著负相关。结论上海市0~6岁儿童的血砷水平存在性别差异,与膳食等因素有关,并与儿童体格生长存在负向关联。
Objective To obtain a cross-sectional data of children in Shanghai on blood arsenic levels,influencing factors,and to evaluate the relationship between arsenic exposure and children′s physical growth,in order to provide reference for the prevention and intervention of health problems caused by arsenic exposure.Methods A total of 2263 children aged 0-6 years in Shanghai,recruited between 2013 and 2015,with available blood samples,anthropometric growth indicators,and baseline demographic data were selected as study subjects.Total arsenic levels in whole blood were measured using inductively coupled plasma mass spectrometry(ICP-MS/MS).Associations between arsenic exposure and children′s physical growth were analyzed using univariate linear regression and multivariable linear regression.Results The median blood arsenic level in Shanghai children was 1.57μg/L.Girls had higher blood arsenic levels than boys(1.67μg/L vs.1.47μg/L,Z=510794.50,P<0.05);children whose primary caregivers smoked had higher blood arsenic levels than those whose caregivers did not smoke(1.83μg/L vs.1.52μg/L,Z=275783.00,P<0.05);children who frequently consumed sea fish and freshwater fish had higher blood arsenic levels than those who occasionally consumed sea fish(1.69μg/L vs.1.34μg/L,Z=417778.00,P<0.05)and freshwater fish(1.69μg/L vs.1.37μg/L,Z=443342.00,P<0.05).After adjusting for parental height,weight,and household income,arsenic exposure level was significantly negatively associated with age-specific height-for-age Z-score(β=-0.08,95%CI:-0.12 to-0.03,P<0.01),weight-for-age Z-score(β=-0.07,95%CI:-0.11 to-0.03,P<0.01),and body mass index(BMI)-for-age Z-score(β=-0.05,95%CI:-0.10 to 0.00,P=0.03).Conclusion There are sex differences in blood arsenic levels among 0-to 6-year-old children in Shanghai,which are related to dietary factors and have a negative correlation with physical growth in children.
作者
林崟
刘军霞
张林
颜崇淮
LIN Yin;LIU Junxia;ZHANG Lin;YAN Chonghuai(MOE-Shanghai Key Laboratory of Children′s Environmental Health,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Department of Labor Health and Environmental Hygiene,School of Public Health,Lanzhou University)
出处
《中国儿童保健杂志》
CAS
CSCD
北大核心
2024年第9期969-973,共5页
Chinese Journal of Child Health Care
基金
国家自然科学基金(81973062)
十三五国家重点研发计划《食品安全关键技术研发》重点专项(2017YFC1600501)
关键词
血砷
电感耦合等离子体质串联谱仪
体格生长
儿童
blood arsenic levels
inductively coupled plasma mass spectrometer
physical growth
children
