摘要
目的探究连续性肾脏替代疗法(CRRT)联合血液灌流治疗重症监护室(ICU)脓毒血症患者的效果。方法选取2022年9月—2023年9月滕州市中医医院收治的78例ICU脓毒血症患者为研究对象,按随机数字表法将其分为对照组及观察组,每组39例。对照组采用血液灌流治疗,观察组在此基础上采用CRRT治疗,均持续1周。比较两组患者的临床疗效、肾功能及炎症因子水平。结果观察组的治疗总有效率为94.87%,高于对照组的76.92%,差异有统计学意义(P<0.05)。治疗后,观察组的尿素氮、血肌酐水平分别为(12.39±1.54)mmol/L、(143.26±12.29)μmol/L,均低于对照组的(20.25±2.40)mmol/L、(195.41±16.54)μmol/L,组间差异有统计学意义(P<0.05)。治疗后,观察组的C反应蛋白、白细胞介素-6、肿瘤坏死因子-α、降钙素原水平分别为(10.53±1.65)mg/L、(20.26±2.69)ng/L、(10.50±1.67)ng/L、(0.53±0.11)ng/L,均低于对照组的(15.21±2.27)mg/L、(39.46±4.47)ng/L、(14.34±2.18)ng/L、(1.23±0.27)ng/L,组间差异有统计学意义(P<0.05)。结论CRRT联合血液灌流可改善ICU脓毒血症患者的肾功能,控制炎症反应,值得临床推广应用。
Objective To investigate the efficacy of continuous renal replacement therapy(CRRT)combined with hemoperfusion in the treatment of sepsis in intensive care unit(ICU).Methods A total of 78 patients with sepsis in ICU admitted to Tengzhou Traditional Chinese Medicine Hospital from September 2022 to September 2023 were selected as the research objects and were divided into a control group and an observation group according to random number table method,with 39 cases in each group.The control group was treated with hemoperfusion,and the observation group was treated with CRRT on this basis.Both groups were treated for 1 week.The clinical efficacy,renal function and inflammatory factor levels were compared between the two groups.Results The total effective rate of the observation group was 94.87%,higher than 76.92%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of blood urea nitrogen and serum creatinine in the observation group were(12.39±1.54)mmol/L and(143.26±12.29)μmol/L,respectively,which were lower than(20.25±2.40)mmol/L and(195.41±16.54)μmol/L in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of C-reactive protein,interleukin-6,tumor necrosis factor-αand procalcitonin in the observation group were(10.53±1.65)mg/L,(20.26±2.69)ng/L,(10.50±1.67)ng/L and(0.53±0.11)ng/L,respectively,which were lower than(15.21±2.27)mg/L,(39.46±4.47)ng/L,(14.34±2.18)ng/L,(1.23±0.27)ng/L in the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion CRRT combined with hemoperfusion can improve renal function and control inflammation in patients with sepsis in ICU,which is worthy of clinical application.
作者
刘书群
LIU Shuqun(Department of Critical Care Medicine,Tengzhou Traditional Chinese Medicine Hospital,Zaozhuang,277599,China)
出处
《反射疗法与康复医学》
2024年第8期111-114,共4页
Reflexology And Rehabilitation Medicine
关键词
脓毒血症
连续性肾脏替代疗法
血液灌流
肾功能
Sepsis
Continuous renal replacement therapy
Hemoperfusion
Renal function
