摘要
目的:探讨异丙酚和氯胺酮麻醉在部分肝切除术(PHT)后的大鼠中对肝再生的影响。方法:将雄性Wistar大鼠随机分为4组,每组8只。组1和组2中的麻醉用异丙酚进行诱导和维持,组3和组4中使用氯胺酮。组1和组3的大鼠行PHT术,组2和组4(对照组)的大鼠进行相同的手术,仅未行PHT术。在术后第5天将大鼠处死,取出再生的肝脏,称重并评估。另外,将收集大鼠血清,用于测量肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6的水平。结果:在组2和组4之间,TNF-α和IL-6水平没有差异,而组1的TNF-α和IL-6的血浆水平跟组3相比有所降低。结论:异丙酚作为一种麻醉药物,可以减弱细胞因子介导的上调,这可能是肝脏切除术后其中的一种保护机制。
Objective:To determine the effects of propofol and ketamine anesthesia on liver regeneration in rats after partial hepatectomy(PHT).Methods:Male Wistar albino rats were assigned randomly and equally into four groups.Anesthesia was induced and maintained with propofol in Groups 1 and 2,and with ketamine in Groups 3 and 4.PHT was undertaken in Groups 1 and 3.Rats in Groups 2 and4(control groups)underwent an identical surgical procedure except for PHT.At postoperative day 5,rats were killed.Regenerated liver was removed,weighed,and evaluated.Blood samples were collected for measurement of levels of tumor necrosis factor(TNF)-αand interleukin-6(IL-6).Results:Between groups 2 and 4,there were no differences in plasma levels of TNF-αand IL-6.Changes of TNF-αand IL-6 levels in Group 1 were fewer than in Group 3.Conclusion:As an anesthetic,propofol can attenuate cytokine-mediated upregulation,which may be one of the protective mechanisms after liver resection.
作者
王永顺
刘蓉
吴迪
WANG Yongshun;LIU Rong;WU Di(Dept.of Anesthesiology,Jianghan Oilfield General Hospital,Qianjiang 433124,Hubei,China;Dept.of Anesthesiology,Renmin Hosital of Wuhan University,Wuhan 430060,Hubei,China)
出处
《武汉大学学报（医学版）》
CAS
2019年第6期883-885,共3页
Medical Journal of Wuhan University
关键词
异丙酚
氯胺酮
肝脏再生
肝切除术
Propofol
Ketamine
Liver Regeneration
Hepatectomy
