摘要
自身免疫性肝炎(autoimmune hepatitis,AIH)是一种以血清自身抗体水平升高、免疫功能失调为特征的慢性肝脏炎症性疾病。其发病机制尚未完全阐明,已知与环境、遗传、动态免疫微环境等因素相关。Th17细胞和Treg细胞是机体免疫相关的两种重要的细胞亚群,二者在功能上相互拮抗。Th17具有促炎性,Treg具有抑炎性。Th17/Treg失衡是AIH的一个重要特征,在AIH的发生、发展中发挥着重要的作用。调节Th17/Treg失衡是治疗AIH的新靶点。本研究对Th17/Treg细胞失衡及其在AIH发生发展中的调节作用进行了综述,并提出应探索下调Th17或上调Treg的干预药物,开发有效疗法,以期为AIH的治疗与预防提供新靶点。
Autoimmune hepatitis(AIH)is a chronic liver inflammatory disease characterized by elevated serum autoantibody level and immune dysfunction.Its pathogenesis has not been fully illustrated,and it is known to be involved in environmental factors,heredity factors,dynamic immunological microenvironment and other factors.Th17 cells and Treg cells are two important subsets related to immunity,which are functionally antagonistic to each other.Th17 is pro-inflammatory and Treg is anti-inflammatory.Th17/Treg imbalance is an important characteristic of AIH,which plays a crucial part in the occurrence and development of autoimmune hepatitis.Regulating Th17/Treg imbalance is a new target for treating AIH.In the present paper,Th17/Treg cell imbalance and its regulatory role in the progression and development of AIH are reviewed,and it proposes exploring intervention drugs that down-regulate Th17 or up-regulate Treg to develop effective therapies,to provide new targets for the treatment and prevention of AIH.
作者
宋明杰
李萍
曾涛
程东
张翠丽
SONG Ming-jie;LI Ping;ZENG Tao;CHENG Dong;ZHANG Cui-li(School of Public Health,Shandong University,Jinan,Shandong 250012,China;不详)
出处
《环境与健康杂志》
CAS
2024年第3期276-281,共6页
Journal of Environment and Health
基金
山东省自然科学基金(ZR2022MH014)
