摘要
目的探讨β-连环蛋白(β-catenin)细胞核阳性表达与高级别胶质瘤患者临床病理因素的相关性及对患者术后生存期的影响。方法收集51例高级别胶质瘤患者手术切除的肿瘤组织标本,免疫组织化学检测β-catenin的细胞核表达状况。收集患者的临床资料,分析细胞核阳性表达及其与多种临床病理因素的相关性。Kaplan-Meier生存分析β-catenin的细胞核表达状况对患者术后生存期的影响。结果51例高级别胶质瘤患者中,β-catenin细胞核阳性表达为26例,占50.98%。β-catenin的核表达与患者年龄、性别、肿瘤大小无相关,与患者的术后生存期显著相关。Kaplan-Meier生存曲线提示β-catenin细胞核阴性表达者术后生存期显著长于细胞核阳性表达者。结论β-catenin细胞核阳性表达是影响高级别胶质瘤患者术后生存期的重要因素,β-catenin可能是高级别胶质瘤患者治疗的重要靶点。
Objective To explore the relationship betweenβ-catenin positive expression and clinicopathological factors in patients with high-grade glioma and its effect on patients’overall survival.Methods A total of 51 tumor tissue specimens of high-grade glioma patients were collected,theβ-catenin expression of nuclear was detected by immunohistochemistry.Theβ-catenin positive expression and its correlation with various clinicopathological factors were analyzed.The effect of theβ-catenin expression on postoperative overall survival of patients was analyzed by Kaplan-Meier survival analysis.Results A total of 26 patients had positive nuclear expression ofβ-catenin,among the 51 high-grade glioma patients,and the percentage of positive expression was 50.98%.The nuclear expression ofβ-catenin was not correlated with patients'age,sex or tumor size,and was significantly correlated with postoperative survival.Kaplan-Meier analysis showed that postoperative survival time of the nuclear negative expression patients were significantly longer than those in the nuclear positive expression patients.Conclusion The nuclear positive expression ofβ-catenin is an important factor affecting postoperative survival of patients with high-grade glioma,β-catenin may be an important therapeutic target of high grade glioma.
作者
杨波
唐伏秋
姚国杰
YANG Bo;TANG Fuqiu;YAO Guojie(Department of Oncology,General Hospital of Central Theater Command,Wuhan Hubei 430070,China)
出处
《华南国防医学杂志》
CAS
2020年第3期161-163,172,共4页
Military Medical Journal of South China
基金
430070湖北省卫生计生委课题(WJ2017H0051)
