摘要
以7-氨基-3-甲基-3-头孢烯-4-羧酸(7-ADCA)为起始原料,与(Z)-2-(2-氨基噻唑-4-基)-2-乙酰氧亚氨基硫代乙酸(S)-2-苯并噻唑酯(地尼活性酯)进行酰化反应、水解得到头孢地尼原料药中杂质3-甲基头孢地尼,总收率达39.69%,并对合成的3-甲基头孢地尼进行了结构表征与确证。
3-Methyl cefdinir was prepared uaing 7-Amino-3-methyl-3-cephem-4-carboxylic acid(7-ADCA)as the starting material and S-thio-benzothiazole-(Z)-2-(2-aminothiazole-4-yl-)-acetoxy imine acetate(cefdinir side chain active ester)as starting materials through reactions including acylation and hydrolysis with a total molar yield of 39.69%.The structurec of 3-methyl cefdinir was confirmed.
作者
杨彩霞
陈亮
何火根
杨硕
谭跃浪
李啸风
厉昆
YANG Cai-xia;CHEN Liang;HE Huo-gen;YANG Shuo;TAN Yue-lang;LI Xiao-feng;LI Kun(Zhejiang Apeloatospo Pharmaceutical Co.,Ltd.,Dongyang 322118,China;Department of Chemistry,Zhejiang University,Hangzhou 310027,China)
出处
《精细化工中间体》
CAS
2019年第6期35-38,共4页
Fine Chemical Intermediates
