摘要
目的:观察神经节甘酯在急性缺血性脑卒中患者救治中的应用效果。方法:将入选的80例急性缺血性脑卒中患者随机分为对照组40例和观察组40例。两组均接受重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗,观察组在此基础上辅以神经节甘酯40mg/d,治疗14 d。比较两组患者治疗前后斯堪的那维亚量表(SSS)评分、简短精神状态评定量表(MMSE)评分,Barthel指数(BI)评分、血清白细胞介素6(IL-6)水平变化;比较两组临床疗效及治疗相关不良反应。结果:观察组总有效率(90.00%)与对照组总有效率(80.00%)比较,差异无统计学意义;治疗后两组SSS评分均下降,观察组3d、7d和14d时SSS评分显著低于对照组;治疗后1月、3月和6月时两组MMSE评分比较,差异均无统计学意义;治疗后14d,观察组BI评分高于对照组,血清IL-6水平低于对照组,差异均有统计学意义;观察组总不良反应发生率(25.00%)与对照组总不良反应发生率(17.50%)比较,差异无统计学意义。结论:急性缺血性脑卒中患者采用rt-PA静脉溶栓后加用神经节甘酯有助于改善神经功能缺损和日常生活能力。
Objective To observe the application effect of ganglioside in the treatment of patients with acute ischemic stroke(AIS).Methods Eighty AIS patients were randomly divided into control group and observation group,40 cases in each group.Both groups were treated with intravenous thrombolysis of recombinant tissue-type plasminogen activator(rt-PA).On this basis,observation group was additionally given 40 mg/d ganglioside treatment for 14d.The changes in scores of Scandinavian stroke scale(SSS),mini-mental state examination(MMSE)and Barthel index(BI),and level of serum interleukin 6(IL-6)before and after treatment were compared between the two groups.The clinical curative effect and treatment-related adverse reactions were compared between the two groups.Results There was no significant difference in total response rate between observation group and control group(90.00%vs 80.00%).After treatment,SSS scores in both groups were decreased.At 3d,7d and 14d,SSS scores in observation group were significantly lower than those in control group.After 1 month,3 months and 6 months of treatment,there was no significant difference in MMSE score between the two groups.After 14d of treatment,BI score in observation group was higher than that in control group,while level of serum IL-6 was lower than that in control group.There was no significant difference in incidence of total adverse reactions between observation group and control group(25.00%vs 17.50%).Conclusion After rt-PA intravenous thrombolysis,the application of ganglioside in AIS patients is conducive to improving neurological deficits and daily living ability.
作者
霍秋玉
张莉星
彭祥旺
Huo Qiu-yu;Zhang Li-xing;Peng Xiang-wang(Emergency Department of Nanjing Mingji Hospital,Nanjing 210019,China)
出处
《湖南师范大学学报（医学版）》
2020年第6期119-122,共4页
Journal of Hunan Normal University(Medical Sciences)
