摘要
手性H3PO4由于其特有的化学结构及催化效果,被广泛的用于不对称合成反应中,近年来人们逐渐提高了对它的认识。手性含氮化合物是有机化学中非常重要的一类化合物,亚胺的不对称反应通常是合成手性有机胺最有效的方法之一。本文简单介绍手性H3PO4及其特点,重点介绍由手性H3PO4催化实现的碳、氧、硫和氮原子对于亚胺的不对称加成反应及亚胺的对映选择性还原反应。
Chiral phosphoric acid catalysts have been widely used in asymmetric synthesis reactions due to their unique chemical structure and excellent catalytic effect.In recent years,people have gradually improved their understanding of chiral phosphoric acid.Chiral nitrogen-containing compounds are a very important class of compounds in organic chemistry.The asymmetric addition reaction of imines is usually one of the most effective meth-ods for the synthesis of chiral organic amines.This article briefly introduces chiral phosphoric acid and its charac-teristics,and focuses on the asymmetric addition reactions of carbon,oxygen,sulfur and nitrogen to imine and enantioselective reduction of imine catalyzed by chiral phosphoric acid.
作者
曹瑞
李红亮
CAO Rui;LI Hong-liang(School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China)
出处
《化学工程师》
CAS
2020年第12期49-53,22,共6页
Chemical Engineer
基金
中国博士后基金委二等资助(No.2018M641642)
关键词
含氮化合物
手性磷酸
亚胺不对称反应
nitrogen-containing compounds
chiral phosphoric acid
asymmetric reaction of imines
