摘要
目的评估抗凝血酶(antithrombin,AT)在脓毒血症患者不同阶段的诊断价值。方法采用单一中心的多因素病理对照研究,收集脓毒血症患者入院后各时间段血清检测AT-Ⅲ活性及其他凝血项目、炎症因子检测结果,多因素配合分析检验特异性和敏感度。结果在脓毒症组中,PT-T、DD、FDP水平显著升高,PLT、Fbg、AT-Ⅲ水平显著降低(P<0.05)。AT-Ⅲ、PT-T、FDP和PLT为脓毒症早期诊断较好的生物学指标;AT-Ⅲ、FDP和PLT可以更准确地预测脓毒症不良预后。结论AT-Ⅲ水平作为单一生物学指标对于脓毒症诊断和判断不良预后具有重要价值。
Objective To evaluate the diagnostic value of antithrombin in different stages of sepsis patients.Methods A single-center multi-factor pathological study was used to collect the AT-Ⅲactivity,the other coagulation events and inflammatory factors in patients with sepsis at various time points after admission.Multi-factor analysis was used to test the relative specificity and sensitivity.Results In the sepsis group,the levels of PT-T,DD,FDP increased significantly,and the levels of PLT,Fbg,AT-Ⅲdecreased significantly(P<0.05).AT-Ⅲ,PT-T,FDP and PLT were better biological indicators for the early diagnosis of sepsis;AT-Ⅲ,FDP and PLT could more accurately predict the poor prognosis of sepsis.Conclusion AT-Ⅲlevel as a single biological indicator has better ability to diagnose and judge the poor prognosis of sepsis.
作者
吕彩虹
方传丰
杨春
姜晓峰
LV Cai-hong;FANG Chuan-feng;YANG Chun;JIANG Xiao-feng(Department of Clinical Laboratory,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《哈尔滨医科大学学报》
CAS
2020年第5期538-541,共4页
Journal of Harbin Medical University
