摘要
目的采用荟萃分析以更加确切地阐明STK39与高血压之间的关系。方法在PubMed、EMBASE、Web of science、the Cochrane Library等数据库中检索已发表文献,并使用固定或随机效应模型计算95%置信区间(CI)的合并优势比(OR)。结果采用适当的纳入和排除标准,共纳入12项研究,包括来自不同种族的24267名高血压患者和15935名对照组人群。荟萃分析显示STK39 rs3754777 rs35929607 rs6749447变异与高血压无相关性,相对应的OR值,95%CI和P值分别为:[1.15,(0.91,1.46),0.23][0.95,(0.85,1.06),0.37][1.18,(0.87,1.61),0.30]。以种族、实验设计、样本量大小和发表年份为类别对人群进行亚组分析时,显示涉及白种人群的研究(OR=1.37,95%CI=1.16,1.62,P<0.05),设计类型为前瞻性设计的研究(OR=1.36,95%CI=1.01,1.83,P<0.05),样本量≥1500(OR=1.44,95%CI=1.01,2.06,P<0.05)以及发表年份为2014年之前(不包括2014)(OR=1.11,95%CI=1.02,1.22,P<0.05)的研究是有统计学意义的,这些研究说明位点rs3754777与高血压发生存在相关性。通过敏感性分析进一步证实了研究结果的稳定性,未检测到出版偏倚。结论荟萃分析证实了STK39与高血压不存在显著的相关性,不建议针对SPAK激酶影响血压水平的机制开发新的防治措施。
Objective We conducted a meta-analysis to clarify the association between STK39 and hypertension.Methods Published literatures from PubMed,EMBASE,Web of science,and the Cochrane Library were retrieved,and combined odds ratios(OR)of 95%confidence intervals(CI)were calculated using fixed or random effects models.Results Using appropriate inclusion/exclusion criteria,we identified twelve studies that included 24,267 patients with hypertension and 15,935 controls from various ethnic groups.Meta-analysis showed no correlation between STK39 rs3754777 rs35929607 rs6749447 and hypertension.The corresponding OR values,95%CI and p values were:[1.15,(0.91,1.46),0.23],[0.95,(0.85,1.06),0.37],[1.18,(0.87,1.61),0.30].In subgroup analysis of populations by race,experimental design,sample size,and year of publication,we showed that studies involving white populations(OR=1.37,95%CI=1.16,1.62,P<0.05)and prospective design studies(OR=1.36,95%CI=1.01,1.83,P<0.05),sample size≥1500(OR=1.44,95%CI=1.01,2.06,P<0.05),and publication year prior to 2014(excluding 2014)(OR=1.11,95%CI=1.02,1.22,P<0.05)were statistically significant.These studies indicate that site rs3754777 is associated with hypertension.We further confirmed the results through sensitivity analysis.No publication bias was detected.Conclusions The present meta-analysis confirmed no significant association between STK39 and hypertension,and it is not recommended to study the pathogenesis of SPAK kinase as a preventive measure for hypertension.
作者
宋华忠
张廷峰
范艳存
SONG Hua zhong;ZHANG Ting feng;FAN Yan cun(School of Public Health,Inner Mongolia Medical University,Hohhot,Inner Mongolia 010000,China;School of Health Management,Inner Mongolia Medical University,Hohhot,Inner Mongolia 010000,China)
出处
《疾病监测与控制》
2023年第3期169-174,共6页
Journal of Diseases Monitor and Control
