摘要
淋巴细胞抗原6E(LY6E)是LY6/uPAR超家族成员之一,通过其C端的糖基磷脂酰肌醇锚定在细胞膜表面。LY6E在T细胞发育和活化、肿瘤细胞生长和迁移以及病毒感染中发挥着重要作用。LY6E广泛表达于人的多种组织器官中,但与正常细胞相比,其在多种癌细胞中的表达量均明显升高。因此,LY6E被视为治疗恶性肿瘤的潜在靶点,目前靶向LY6E的抗体药物偶联物DLYE5953A已完成临床Ⅰ期试验。此外,LY6E能影响冠状病毒、人类免疫缺陷病毒、甲型流感病毒和登革热病毒等多种病毒感染,其第36位的亮氨酸在病毒感染过程中发挥着重要作用。对LY6E的深入研究,可为人类应对恶性肿瘤和病毒感染治疗提供新的策略。该文将对LY6E的生物学功能进行综述。
Lymphocyte antigen 6E(LY6E)is a member of LY6/uPAR superfamily,which is located in the cell surface via C terminal glycosylphosphatidylinositol.LY6E plays important roles in T cell development and activation,tumor cell migration and invasion,and viral infection.LY6E is widely expressed in human tissues and organs,but LY6E expression levels are significantly higher in various cancer cells than in normal cells.Therefore,LY6E is regarded as a therapeutic target to cancer.An antibody-drug conjugate DLYE5953A targeting LY6E has completed phaseⅠtrial.Besides,LY6E also influences various viral infections including coronavirus,human immunodeficiency virus,influenza A virus,and dengue virus,and leucine 36 is essential for these infections.More study of LY6E will offer more effective strategies against cancer and viral infections.This article will review the biological functions of LY6E.
作者
刘曜宁
朱林
王丹丹
高婷
曹诚
LIU Yao⁃ning;ZHU Lin;WANG Dan⁃dan;GAO Ting;CAO Cheng(Institute of Physical Science and Information Technology,Anhui University,Hefei 230000,China;State Key Laboratory of Pathogen Biosecurity,Beijing Institute of Biotechnology,Beijing 100850,China;PLA 307 Clinical College,Anhui Medical University,Beijing 100071,China)
出处
《军事医学》
CAS
2021年第10期786-792,共7页
Military Medical Sciences
基金
国家科技重大专项(2018ZX09711003-005-005)
