摘要
严重创伤、感染、肿瘤及骨骼肌肉系统先天性畸形所导致骨缺损的修复重建已成为骨科医生面临的巨大挑战。等离子体表面改性修饰技术在不使用溶剂和不产生化学废物的情况下,通过蚀刻、化学反应和离子辐射等方法改变高分子聚合物表面的组成和微观结构,并通过涂层、嫁接和蛋白质固定等手段制造仿生表面结构,显著增加了生物相容性,进而促进细胞的附着、增殖和分化,为新生骨组织的生长和血管化提供了有力保障,成为骨组织工程领域中的研究热点并得到了广泛应用。
Reconstruction of bone defects caused by severe trauma, infection, tumor and congenital malformation of musculoskeletal system has become a challenge for orthopaedic surgeons. By etching, chemical reaction and ionizing radiation without using solvent or generating chemical waste, plasma surface modification techniques not only change the composition and microstructure of the polymer surface, but also fabricate the bionic surface structures by means of coating, grafting and protein fixation, which significantly promotes cell attachment, proliferation and differentiation, thereby promoting the growth and vascularization of new bone tissues. Plasma surface modification has become a research hotspot in the field of bone tissue engineering and has been widely used.
作者
李明
刘建恒
崔翔
张里程
唐佩福
LI Ming;LIU Jianheng;CUI Xiang;ZHANG Licheng;TANG Peifu(Department of Orthopaedics,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)
出处
《解放军医学院学报》
CAS
2020年第1期84-87,共4页
Academic Journal of Chinese PLA Medical School
基金
国家重点研发计划课题(2016YFC1102005)
国家自然科学基金(81702121,81702153)
首发科研专项(2018-4-5014)
全军后勤科研计划重大项目(AWS17J004)
解放军总医院临床科研扶持基金(2017FC-TSYS-2006).
