摘要
纤维蛋白原样蛋白2(fibrinogen-like protein 2,FGL2)是纤维蛋白原家族的一员,分为具有凝血活性的膜相关型蛋白和具有免疫调节功能的分泌型蛋白两大类。随着移植事业的不断发展,获得移植免疫耐受成为了移植医生的终极目标,FGL2在移植免疫耐受中的作用受到了广泛的关注。本文对FGL2在实体器官移植中的作用机制进行全面的综述。
Fibrinogen-like protein 2(FGL2),a member of the fibrinogen family,can be classified into membrane-associated protein with coagulation activity and a secreted form possessing immune suppressive functions.With the development of transplantation,immune tolerance has become the ultimate goal of transplant physicians,and the role of FGL2 in immune tolerance has been widely concerned.This article will provide a comprehensive review of the role of FGL2 in solid organ transplantation.
作者
张欣雪
吕少诚
李先亮
贺强
ZHANG Xinxue;LYU Shaocheng;LI Xianliang;HE Qiang(Department of Hepatobiliary Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)
出处
《解放军医学院学报》
CAS
2020年第5期532-534,547,共4页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金面上项目(81571825)
