摘要
脓毒症是机体为应对严重危及生命的感染而产生的全身炎症性疾病,其病理过程涉及多个系统脏器,肺组织是其中最早、最易受累的器官,脓毒症导致的急性肺损伤(acute lung injury,ALI)病死率高达40%,然而其发病机制尚不完全清楚,积极探索本病的发病机制,不仅具有重要理论意义,同时可能为本病的治疗提供新的策略。非编码RNA(non-coding RNA,ncRNA)是一类不能编码蛋白质的RNA,目前关于非编码RNA中的微小RNA、长链非编码RNA以及环状RNA的研究日益广泛,其中与脓毒症急性肺损伤发病机制相关的研究日益增多。本文就近年来针对ncRNA在脓毒症急性肺损伤发病机制中的研究进展做一综述。
Sepsis is a systemic inflammatory disease caused by the body’s response to life-threatening infection.Its pathological process involves multiple systems and organs,among which lung is the first and most vulnerable organ.The mortality rate of acute lung injury caused by sepsis is as high as 40%.However,its pathogenesis is still unclear.Exploring the pathogenesis of this disease has important significance.Meanwhile,it may provide a new strategy for the treatment of the disease.Non-coding RNA is a type of RNA that cannot encode proteins.At present,researches on microRNAs,long-chain noncoding RNAs and circular RNAs in non-coding RNA family are becoming more and more extensive,and the research related to the pathogenesis of acute lung injury secondary to sepsis is also increasing.This article summarizes research advances in role of noncoding RNA in acute lung injury in sepsis.
作者
张莉
张传涛
高培阳
ZHANG Li;ZHANG Chuantao;GAO Peiyang(Clinical Medicine College of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China;Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan Province,China)
出处
《解放军医学院学报》
CAS
2020年第6期644-647,共4页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金项目(81873298)
