摘要
目的探讨水通道蛋白4(AQP4)在乳腺癌发展中的作用机制。方法选用高表达AQP4的T47D及MCF-7细胞系,通过50siRNA干扰技术下调乳腺癌细胞T47D和MCF-7细胞系中AQP4的表达水平,检测下调的AQP4对乳腺癌细胞侵袭及转移的影响。结果下调的AQP4能够显著的抑制乳腺癌细胞的侵袭及转移。结论AQP4表达水平与乳腺癌病情发展有相关性,可以进一步开发成为新的靶点。
Objective To investigate the mechanism of aquaporin 4(AQP4)in the development of breast cancer.Methods The expression of aquaporin 4 in the T47 D and MCF-7 cell lines of breast cancer cells was downregulated by siRNA interference,and the effect of this down regulation on the invasion and metastasis of breast cancer cells was detected.Results Decreased expression of AQP4 inhibits invasion and metastasis of breast cancer cells.Conclusion The expression level of AQP4 is correlated with the development of breast cancer,and it can further develop into a new target.
作者
李英彬
孙圣荣
Li Yingbin;SUN Shengrong(Department of Breast Surgery,Inner Mongolia people's Hospital,Hohhot 010017,China)
出处
《临床外科杂志》
2020年第1期54-57,共4页
Journal of Clinical Surgery
基金
内蒙古自治区人民医院院内基金资助项目(92016032).
