摘要
目的探讨老年慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)和阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)重叠综合征患者的睡眠质量。方法选取2018年2月至2019年2月浙江医院收治的COPD患者45例(COPD组)、OSA患者45例(OSA组)、OS患者48例(OS组),以及同期体检健康志愿者28例(健康对照组),收集所有研究对象相关临床资料,分别采用匹兹堡睡眠质量指数量表和多导睡眠监测(PSG)评定主观和客观睡眠质量。多组间的比较采用单因素方差分析和秩和检验,两两比较采用LSD-t检验和Bonferroni法,计数资料的比较采用χ2检验。结果4组研究对象BMI、颈围、ESS评分、一秒用力呼气容积(forced expiratory volume in one second,FEV1)占预计值的百分比及FEV1/用力肺活量(forced vital capacity,FVC)的差异均有统计学意义(F=5.693、12.804、4.805、195.050、452.290,P<0.01)。OS组及OSA组BMI均明显大于健康对照组(P<0.05),OS组BMI明显大于COPD组(P<0.05);OS组及OSA组颈围均明显大于健康对照组和COPD组(P<0.05);OS组及OSA组ESS评分均明显高于健康对照组(P<0.05),OSA组ESS评分明显高于COPD组(P<0.05)。OS组及COPD组FEV1占预计值的百分比、FEV1/FVC均明显大于健康对照组和OSA组(P<0.05)。4组研究对象各项PSG监测指标的差异均有统计学意义(F=806.326、59.965、8.916、24.168、81.969、15.666,P<0.01)。OS组及OSA组呼吸暂停低通气指数、最长呼吸暂停时间均明显高于健康对照组和COPD组(P<0.05),OS组呼吸暂停低通气指数、最长呼吸暂停时间均明显高于OSA组(P<0.05);OS组微觉醒指数、平均血氧饱和度、最低血氧饱和度及血氧饱和度<90%占监测总时间的百分比均明显高于其他各组(P<0.05)。4组研究对象除主观总睡眠时间及客观睡眠潜伏期外的其他各指标的差异均有统计学意义(F=5.196、6.470、10.444、6.785、2.947、8.591、7.452,P<0.05或0.01)。OS组、OSA组及COPD组主观入睡后觉醒总
Objective To investigate the sleep quality of elderly patients with overlap syndrome(OS)of chronic obstructive pulmonary disease(COPD)and obstructive sleep apnea(OSA).Methods 166 elderly patients admitted to Zhejiang Hospital from February 2018 to February 2019 were selected,including 45 COPD patients(COPD group),45 OSA patients(OSA group),48 OS patients(OS group),and 28 healthy volunteers in the same period(healthy control group).The clinical data of all subjects were collected,Pittsburgh sleep quality index scale and polysomnography(PSG)were used to evaluate subjective and objective sleep quality.Univariate analysis of variance and rank sum test were used for comparison among multiple groups,LSD-t test and Bonferroni method were used for pairwise comparison,and counting data were compared byχ2 inspection.Results There were significant differences in BMI,neck circumference,ESS score,percentage of forced expiratory volume in one second(FEV1)and FEV1/forced vital capacity(FVC)among the four groups(F=5.693,12.804,4.805,195.050,452.290,P<0.01).The BMI of OS group and OSA group was significantly higher than that of healthy control group(P<0.05),and the BMI of OS group was significantly higher than that of COPD group(P<0.05).The neck circumference of OS group and OSA group was significantly higher than that of healthy control group and COPD group(P<0.05).The ESS score of OS group and OSA group was significantly higher than that of healthy control group(P<0.05),and the ESS score of OSA group was significantly higher than that of COPD group(P<0.05).The FEV1%and FEV1/FVC in OS group and COPD group were significantly higher than those in healthy control group and OSA group(P<0.05).There were significant differences in PSG monitoring indexes among the four groups(F=806.326,59.965,8.916,24.168,81.969,15.666,P<0.01).The apnea hypopnea index and the longest apnea time in OS group and OSA group were significantly higher than those in healthy control group and COPD group(P<0.05).The apnea hypopnea index and the longest apnea t
作者
杜坚宗
陆晓玲
吴万振
唐婷玉
Du Jianzong;Lu Xiaoling;Wu Wanzhen;Tang Tingyu(Department of Respiratory Medicine,2Department of Psychiatry,Zhejiang Hospital,Hangzhou 310013,China)
出处
《中华老年病研究电子杂志》
2021年第2期17-21,共5页
Chinese Journal of Geriatrics Research(Electronic Edition)
基金
浙江省基础公益研究计划项目(LGF18H010002)
关键词
慢性阻塞性肺病
阻塞性睡眠呼吸暂停
重叠综合征
睡眠质量
主观
客观
Chronic obstructive pulmonary disease
Obstructive sleep apnea
Overlap syndrome
Sleep quality
Subjective
Objective
