摘要
目的探讨额叶低级别胶质瘤全切术后复发的相关因素。方法回顾性分析62例经临床及病理证实的WHO II级额叶胶质瘤全切患者的临床资料,统计分析术后复发的可能因素,包括年龄、性别、放化疗与否、左右侧别、肿瘤直径、病理类型、增殖指数(Ki-67)、IDH1是否突变等。结果单因素分析结果显示:年龄、化疗、Ki-67、IDH1对于额叶低级别胶质瘤全切术后复发有统计学意义(P<0.05);性别、放疗、侧别、直径、病理类型对复发无统计学意义(P>0.05)。Logistic回归分析结果显示:年龄(OR=1.178,P<0.05)、术后化疗(OR=84.987,P<0.05)、增殖指数(Ki-67)(OR=0.014,P<0.05)是额叶低级别胶质瘤全切术后复发的危险因素。结论对于低级别胶质瘤患者在不影响神经功能的前提下应尽量全切肿瘤;对于年龄偏大,增殖指数较高的患者,术后更应严格定期复查,密切随访。
Objective To investigate the factors related to postoperative recurrence in frontal low-grade gliomas after neurosurgeon-determined gross-total resection.Methods Clinical data of 62 frontal WHO II glioma patients who were comfirmed by neurosurgeon and pathological examination were analyzed retrospectively.The possible factors of postoperative recurrence including gender,age,location,diameter of tumor,whether radiotherapy or chemotherapy or not,pathological type,proliferation index(Ki-67)and IDH1(wild type or mutation type)were analyzed statistically.Results The results of single factor analysis showed that age,chemotherapy,proliferation index(Ki-67)and IDH1 were statistically significant for postoperative recurrence in LGG patients under neurosurgeon-determined gross-total resection(P<0.05).While gender,radiotherapy,tumor location,diameter of tumor and pathological type were not statistically significant for postoperative recurrence(P>0.05).Logistic regression analysis showed that age(OR=1.178,P<0.05),chemotherapy(OR=84.987,P<0.05),and proliferation index(Ki-67)(OR=0.014,P<0.05)were risk factors for postoperative recurrence.Conclusion For patients with frontal low-grade glioma,the tumor should be completely removed as far as possible on the premise of not affecting nerve function.For patients with older age and higher proliferation index,more strict regular review and close follow-up should be conducted after surgery.
作者
杨洋
Yang Yang(Department of Neurosurgery,The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital),Anhui Provincial Stereotactic Neurosurgical Institute,Anhui Province Key Laboratory of Brain Function and Brain Disease,Hefei,230001,P.R.China)
出处
《立体定向和功能性神经外科杂志》
2020年第5期280-284,共5页
Chinese Journal of Stereotactic and Functional Neurosurgery
基金
中国科学技术大学新医学联合基金培育项目(编号:WK9110000128)
安徽省自然科学基金青年项目(编号:20192C024)
关键词
低级别胶质瘤
复发
KI-67
回归分析
Low grade glioma
Recurrence
Ki-67
Logistic regression analysis
