摘要
泛素-蛋白酶体系统(UPS)它在细胞内发挥着重要的作用,可以促进蛋白质降解,参与调节多种生物过程如调控细胞周期、免疫应答、DNA损伤修复、信号传导等。UPS选择性的蛋白质降解和调节功能参与精子发生中的DNA修复、鱼精蛋白组蛋白替换等过程,在精子发生中扮演重要角色。蛋白磷酸酶2A(PP2A)是一种重要的丝氨酸/苏氨酸磷酸酶,参与多种生命活动。有研究表明UPS对PP2A的泛素化发挥着重要作用,PP2A参与了减数分裂的多个步骤,在减数分裂过程中至关重要。现就UPS与PP2A在精子生成中的功能作一简要介绍。
The ubiquitin proteasome system(UPS)plays an important role in cell degradation,and is involved in many biological processes such as cell cycle regulation,immune response,DNA damage repair,and signal transduction.It also acts a crucial part in spermatogenesis by selectively degrading proteins and regulating such processes as DNA repair and protamine histone replacement.PP2A,as an essential serine/threonine phosphatase,participates in a variety of life activities.Studies have shown the involvement of UPS in the ubiquitination regulation of PP2A and that of PP2A in several stages of meiosis.This review updates the roles of UPS and PP2A in spermatogenesis.
作者
陈冰雁(综述)
陈霞(综述)
史轶超(审校)
CHEN Bing-yan;CHEN Xia;SHI Yi-chao(Dalian Medical University,Dalian,Liaoning 116000,China;Changzhou Medical Center,Nanjing Medical University,Changzhou,Jiangsu 213001,China;Center of Reproductive Medicine,Changzhou Second People's Hospital,Changzhou,Jiangsu 213001,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2023年第4期369-374,共6页
National Journal of Andrology
基金
常州市科技资助计划(CJ20230073)
常州市“龙城医星”卫生青年科技人才推举工程(LCYX202201)
南京医科大学常州医学中心科研项目(CMCB202303)
