摘要
目的:探讨前列腺小细胞癌的临床表现、诊断方法、病理特征及治疗方法,以期提高对前列腺小细胞癌的进一步认识。方法:回顾性分析2017年11月至2018年3月收治的2例确诊前列腺小细胞癌的临床及病理资料,并复习相关文献。结果:2例患者均有排尿困难症状,PSA均有升高,前列腺触诊有II°~III°增大,其中1例行前列腺穿刺活检,1例行经尿道前列腺部肿瘤1470激光汽化切除术。术后病理均提示前列腺腺癌伴前列腺小细胞癌,1例患者行EP方案化疗,于确诊20个月后死于全身多器官功能衰竭;1例患者行内分泌治疗,目前带瘤存活。结论:前列腺小细胞癌发病率低,恶性程度高。确诊后平均生存期约7~10个月,目前仍无可靠治疗方案,现基本参照肺小细胞癌的治疗经验,仍以化疗为主,该病预后较差,治疗效果多不满意。
Objective:To explore the clinical manifestations,diagnosis,pathological features and treatment of small-cell carcinoma of the prostate(SCCP).Methods:We conducted a retrospective analysis of the clinical and pathological data of 2 cases of confirmed SCCP treated from November 2017 to March 2018,and reviewed relevant literature.Results:Both the patients had the symptoms of frequent,urgent and difficult urination,with an elevated level of PSA and gradesⅡ-Ⅲenlargement of the prostate at palpation.One underwent prostate puncture biopsy and the other received transurethral 1470 laser vaporization resection of the tumor.Postoperative pathology indicated prostate adenocarcinoma accompanied by SCCP in both of the cases.One of them was treated by etoposide-platinum(EP)chemotherapy and died of systemic multiple organ failure 20 months after diagnosis,while the other underwent endocrine therapy and has lived with tumor up to the present day.Conclusion:The incidence rate of SCCP is low,its malignancy is high,and its prognosis is poor.The average survival of the patient is about 7 to 10 months after diagnosis.Currently there is no effective management of the dissease,except by relying on the experience of the treatment of small-cell lung cancer,with chemotherapy as the main option.
作者
陆龙伟
石秀全
许松
吴鼎
王磊
傅点
徐振宇
LU Long-wei;SHI Xiu-quan;XU Song;WU Ding;WANG Lei;FU Dian;XU Zhen-yu(Department of Urology,General Hospital of Eastern Theater Command,Nanjing/Jinling Hospital Affiliated to Nanjing University School of Medicine,Nanjing,Jiangsu 210002,China;Department of Pathology,General Hospital of Eastern Theater Command,Nanjing/Jinling Hospital Affiliated to Nanjing University School of Medicine,Nanjing,Jiangsu 210002,China)
出处
《中华男科学杂志》
CAS
CSCD
2024年第1期40-43,共4页
National Journal of Andrology
关键词
前列腺恶性肿瘤
小细胞癌
carcinoma of the prostate
small-cell carcinoma
treatment
