摘要
目的探讨乳腺导管内原位癌(DCIS)的MRI特征与HER-2表达的相关性。方法回顾性分析2018年9月—2021年6月在德州市第二人民医院经手术病理证实的53例乳腺DCIS患者分为HER-2阳性组29例,HER-2阴性组24例,比较2组间MRI特征的差异。结果2组间内部强化特征、微血管征、TIC类型差异有统计学意义(P<0.05);病灶形态学、非肿块样强化分布形式、ADC值差异无统计学意义(P>0.05)。HER-2阳性组以集群状强化(65.5%)为主,TIC类型以Ⅱ型(48.1%)、Ⅲ型(29.6%)为主,微血管征(89.7%);HER-2阴性组以簇环状强化(50.0%)为主,TIC类型以Ⅱ型(45.8%)、Ⅰ型(54.2%)为主,微血管征(54.2%);集群状强化,微血管征、TICⅢ型3个参数同时具备诊断HER-2阳性的特异度及阳性预测值均为100%。结论MRI参数中集群状强化、微血管征及TICⅡ型或Ⅲ型曲线在较大程度上能反映乳腺DCIS中HER-2表达情况,三者联合应用可提高HER-2阳性的诊断效能。
Objective To investigate the correlation between the features of multimodal magnetic resonance imaging(MRI)and the expression of human epidermal growth factor receptor-2(HER-2)in ductal carcinoma in situ(DCIS).Methods A total of 53 patients with DCIS confirmed by surgery and pathology in Dezhou Second People’s Hospital from September 2018 to June 2021 were analyzed retrospectively.The patients were divided into HER-2 positive group(29 cases)and HER-2 negative group(24 cases).MRI features were compared between the two groups.Results There were significant differences in the internal enhancement characteristics,microvascular sign,and time-intensity curve type between the two groups(P<0.05).There were no significant differences in lesion morphology,non-mass-like enhancement pattern,and apparent diffusion coefficient value(P>0.05).The HER-2 positive group showed clumped enhancement(65.5%),typeⅡ(48.1%)andtypeⅢ(29.6%)time-intensity curves,and microvascular sign(89.7%).The HER-2 negative group showed clusteredring enhancement(50.0%),typeⅡ(45.8%)and type I(54.2%)time-intensity curves,and microvascular sign(54.2%).A combination of clumped enhancement,microvascular sign,and typeⅢtime-intensity curve showed 100%specificity and 100%positive predictive value for the diagnosis of HER-2 positive DCIS.Conclusion Clumped enhancement,microvascular sign,and typeⅡorⅢtime-intensity curve on MRI can largely reflect the expression of HER-2 in DCIS.The three can be used in combination to improve the diagnostic efficiency of HER-2 positive DCIS.
作者
滕敏敏
邵元伟
方娟娟
张丽伟
刘廷洲
李华芳
TENG Minmin;SHAO Yuanwei;FANG Juanjuan;ZHANG Liwei;LIU Tingzhou;LI Huafang(Dezhou Second People’s Hospital,Medical Imaging Center,Dezhou 253004 China;Pathology Department,Dezhou 253004 China)
出处
《中国辐射卫生》
2022年第4期507-511,共5页
Chinese Journal of Radiological Health
关键词
乳腺导管内原位癌
MRI
HER-2
集群状强化
Ductal carcinoma in situ
MRI
Human epidermal growth factor receptor-2
Clumped enhancement
