摘要
用超声聚合法制备了γ-聚谷氨酸(γ-PGA)接枝胆甾醇(CHOL)纳米胶束(γ-PGA/CHOL·NPs),并考察了γ-聚谷氨酸浓度、胆甾醇浓度、溶液pH值、聚合温度、超声频率和超声时间等因素对该纳米胶束粒径和峰强度的影响。运用筛选试验设计和Box-Behnken实验设计(BBD)对实验结果进行设计和优化,并通过优化条件下的实验验证,获得γ-聚谷氨酸接枝胆甾醇纳米胶束的平均粒径为170.9 nm,与模型预测吻合,得到稳定均一的γ-聚谷氨酸接枝胆甾醇纳米胶束。
In this paper,γ-PGA grafted cholesterol nanoparticles(γ-PGA/CHOL·NPs)were prepared by ultrasonic polymerization.The effects of the concentration ofγ-PGA and cholesterol,pH value of solution,polymerization temperature,ultrasonic frequency and ultrasonic time on the particle size and peak intensity of the nanoparticles were investigated.Plackett Burman experimental design and box Behnken experimental design were used to design and optimize the experimental results.The average particle size ofγ-PGA grafted cholesterol nanoparticles was 170.9 nm,which was consistent with the model prediction.Stable and uniformγ-PGA grafted cholesterol nanoparticles were obtained.
作者
李睿
阮文辉
王宇
郝瑞
Li Rui;Ruan Wenhui;Wang Yu;Hao Rui(College of Traditional Chinese Medicine and Food Engineering,Shanxi University of Chinese Medicine,Taiyuan 030024,China;Shanxi Center of Drug Evaluation(Shanxi Institute of Medicine and Life Science),Taiyuan 03006,China)
出处
《山东化工》
CAS
2021年第8期10-14,共5页
Shandong Chemical Industry
基金
山西省应用基础研究(青年科技研究基金)项目(201801D221278)
山西省中医药科研课题(2020ZYYC098)
山西省重点研发计划项目(201903D321112)
关键词
纳米胶束
Γ-聚谷氨酸
胆甾醇
超声聚合法
nanoparticles
γ-polyglutamic acid
cholesterol
ultrasonic polymerization
