摘要
血管钙化(vascular calcification,VC)在糖尿病、慢性肾脏病、及心血管疾病等患者中是一种常见的病理过程,表现为羟基磷灰石在血管壁上沉积。硫化氢(hydrogen sulfide,H_(2)S)是继NO和CO之后在哺乳动物中发现的第三种气体信号分子,它在心血管系统中具有抗炎、抗氧化应激等作用。近年来,人们已经认识到H_(2)S具有抗VC的作用,补充H_(2)S及其供体可以减轻VC。本文综述了H_(2)S对VC起保护作用的多种证据,并强调了在VC发展过程中H_(2)S代谢改变,及H_(2)S对VC病理生理改变的调控机制。
Vascular calcification is a common pathological process in patients with diabetes,chronic kidney disease,and cardiovascular disease,manifested by the deposition of hydroxyapatite on the walls of blood vessels.Hydrogen sulfide is the third gas signal molecule found in mammals after nitric oxide and carbon monoxide,which has anti-inflammatory,antioxidant stress and other effects in the cardiovascular system.In recent years,it has been recognized that hydrogen sulfide has an anti-vascular calcification effect,and supplementation with hydrogen sulfide and its donors can alleviate vascular calcification.In this review,we discussed the various evidence of the protective effect of hydrogen sulfide on vascular calcification,and highlighted the hydrogen sulfide metabolism changes and the potential regulatory mechanisms of hydrogen sulfide on the pathophysiological changes in vascular calcification.
作者
马建帅
陈洁
黄辉
MA Jian-Shuai;CHEN Jie;HUANG Hui(Department of Cardiology,The Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen 518033,China;Department of Radiation Oncology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510000,China)
出处
《生理学报》
CAS
CSCD
北大核心
2022年第6期903-912,共10页
Acta Physiologica Sinica
基金
supported by the National Key Research and Development Program of China(No.2020YFC2004405)
the National Natural Science Foundation of China(No.8201101103,81870506,91849208,81670676,and 81422011)
Project of Traditional Chinese Medicine in Guangdong Province(No.20201062)
Basic Research Project of Shenzhen Science and Technology Innovation Committee(No.JCYJ20180306174648342 and JCYJ20190808102005602)
Shenzhen Futian District Public Health Research Project(No.FTWS2019003)
the Shenzhen Key Medical Discipline Construction Fund(No.SZXK002)to HUANG Hui
supported by the National Natural Science Foundation of China(No.82073408)to CHEN Jie
关键词
血管钙化
硫化氢
代谢
vascular calcification
hydrogen sulfide
metabolism
