摘要
P2X受体是一类离子型配体门控通道,分为7个不同的亚型(P2X1~7)。嘌呤能离子通道型受体7(purinergic ligand-gated ion channel 7 receptor,P2X7R)是ATP门控的,非选择性的阳离子通道,属于嘌呤受体P2X家族。P2X7受体广泛表达于神经系统、肌肉组织和免疫系统。在胞外ATP作用下,P2X7受体偶联多种胞内信号通路,参与细胞增殖、凋亡及炎症因子的释放等多种生理功能。研究发现,P2X7受体与诸多疾病有着密切联系,包括自身免疫性疾病(如关节炎和炎症性肠病)、神经退行性疾病、慢性疼痛、情绪障碍和癌症等。P2X7受体异常表达会导致这些疾病的发生,增加疾病的易感性与病变程度。现就P2X7受体的生物学特征、P2X7受体与疾病的关系及其特异性阻断剂和激动剂进行综述。
P2X receptors are divided into seven receptor subtypes,P2X1-P2X7.The P2X7 receptor(P2X7R)is a unique subtype among the family of seven purinergic P2X receptors,which are ATP-gated non-selective cation channels.P2X7R is expressed in a broad spectrum of tissues,such as the nervous system,muscle and the immune system.P2X7R can be activated by extracellular ATP and results in a number of downstream events,such as cell proliferation,cell signaling pathways,cytokine secretion,apoptotic cell death.P2X7R has been reported to have pathological roles in various diseases,including autoimmune diseases such as arthritis and inflammatory bowel disease,neurodegenerative diseases,chronic pain,mood disorders and cancers.Abnormal expression of P2X7R will lead to the occurrence of diseases and increase the susceptibility and degree of disease.In this review,the biological function,antagonists and agonists of the P2X7R will be discussed,and their role in the pathogenesis of a wide variety of diseases.
作者
谢玉霜
包永芬
陶喆
白育庭
单士刚
杨军
XIE Yushuang;BAO Yongfen;TAO Zhe;BAI Yuting;SHAN Shigang;YANG Jun(School of Pharmacy,Hubei University of Science and Technology,Xianning 437100,China;Research Center of Basic Medical Sciences,School of Basic Medical Sciences,Hubei University of Science and Technology,Xianning 437100,China;Hubei University of Science and Technology Clinical Medical School,Xianning 437100,China;School of Medicine,Hangzhou Normal University,Hangzhou 310016,China)
出处
《生命的化学》
CAS
CSCD
2020年第1期57-63,共7页
Chemistry of Life
基金
2018年咸宁市科技计划项目(XNKJ-1811)
临床医学重点(培育)学科专项科研项目项目(LCZX201512)
湖北科技学院2017年度药学重点学科专项科研项目(2018-19XZY01).
