摘要
骨关节炎是常见的退行性关节疾病,在老年人群中发病率较高。尽管已有一些药物可用于缓解骨关节炎导致的疼痛,但现已上市的药物在骨关节炎治疗上的效果有限,且存在一定程度的不良反应,使骨关节炎在临床治疗上无法达到十分满意的效果。对此,国内外对用于骨关节炎的化学药、生物药、中药的治疗研发进行了诸多探索,这些研发为改善骨关节治疗的效果带来了新希望。本文对骨关节炎治疗用药的研发进展进行综述,尤其是对已进入临床研究阶段的骨关节炎治疗用化学药、生物药研究进展进行了比较分析,以期为相关研发人员提供启示。
Osteoarthritis is a common degenerative joint disease with a high prevalence in the aged population.Although there are some medicine that can be used to relieve the pain caused by osteoarthritis,the approved medicine have limited effects and some side effects,making it impossible to achieve very satisfactory results in clinical treatment of osteoarthritis.In this regard,much exploration on the therapeutic development of chemical,biological and traditional Chinese medicine for arthritis has been done both domestically and abroad.The corresponding research has brought new insight to improve the effectiveness of arthritis treatments.This paper does a comprehensive review on the progress of research and development of medicine for the treatment of osteoarthritis,especially a comparative analysis of the research progress of chemical and biological medicine for the treatment of osteoarthritis that have entered the clinical research stage,in order to provide insights for relevant researchers and developers.
作者
周赛
江洪波
陈大明
ZHOU Sai;JIANG Hongbo;CHEN Daming(Shanghai Life Science Information Center,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China)
出处
《生命的化学》
CAS
2023年第1期116-123,共8页
Chemistry of Life
关键词
骨关节炎
治疗
药物
osteoarthritis
treatment
medicine
