摘要
目的溴隐亭与逍遥丸均可治疗高泌乳素血症,但两者联合使用研究较少。本研究旨在探究低剂量溴隐亭联合逍遥丸治疗女性高泌乳素血症性不孕的临床效果。方法选择2016-07-06-2018-11-12本院收治的高泌乳素血症性不孕女性患者84例,根据年龄、病程组间均衡的原则分为两组,每组各42例。对照组采用溴隐亭进行常规治疗(初始1.25mg/d,7d后1.25mg/d),观察组采用低剂量溴隐亭联合逍遥丸治疗(溴隐亭1.25mg/d,逍遥丸18g/d)。对比分析两组临床疗效、血清泌乳素(prolactin,PRL)、排卵率、妊娠率和不良反应发生率。结果观察组治疗总有效率为97.62%,高于对照组的73.81%,差异有统计学意义,χ~2=9.722,P=0.002。治疗后30d观察组血清PRL水平为(27.46±8.21)μg/L,低于对照组的(31.58±9.64)μg/L,差异有统计学意义,t=2.109,P=0.038;治疗后45d观察组血清PRL水平为(20.16±5.81)μg/L,低于对照组的(26.79±6.57)μg/L,差异有统计学意义,t=4.899,P<0.001。观察组排卵率为90.48%,高于对照组的71.43%,χ~2=4.941,P=0.026;妊娠率为80.95%,高于对照组的59.52%,χ~2=4.613,P=0.032;不良反应发生率为2.38%,低于对照组的19.05%,差异有统计学意义,χ~2=4.480,P=0.014。结论低剂量溴隐亭联合逍遥丸治疗女性高泌乳素血症性不孕,可有效降低血清PRL水平,提高排卵率和妊娠率,且安全性较高,临床疗效显著。
OBJECTIVE Both bromocriptine and Xiaoyao pill can treat hyperprolactinemia,but there are few studies on their combined use.Therefore,this study aims to investigate the clinical effect of low-dose bromocriptine combined with Xiaoyao pill in the treatment of female infertility due to hyperprolactinemia.METHODS A total of 84 female patients with infertility due to hyperprolactinemia who admitted in the hospital from July 6,2016 to November 12,2018 were selected as subjects,and they were divided into two groups according to the principle of balanced age and course of disease between groups,with 42 cases in each group.Control group was given routine treatment with bromocriptine(initial 1.25 mg/d and 1.25 mg/d after 7 d),and observation group was treated with low-dose bromocriptine and Xiaoyao pill(bromocriptine 1.25 mg/d,Xiaoyao pill 18 g/d).The clinical efficacy,serum prolactin(PRL),ovulation rate,pregnancy rate and the incidence of adverse reactions were compared between two groups.RESULTS The total curative effective rate of observation group(97.62%)was higher than that of control group(73.81%),and the difference was statistically significant(χ~2=9.722,P=0.002).At 30 days after treatment,the serum PRL level in the observation group was(27.46±8.21)μg/L,which was lower than that in the control group(31.58±9.64)μg/L.The difference was statistically significant,t=2.109,P=0.038.At 45 days after treatment,the serum PRL level in the observation group was(20.16±5.81)μg/L,which was lower than that in the control group(26.79±6.57)μg/L.The difference was statistically significant,t=4.899,P<0.001.The ovulation rate in the observation group was 90.48%,which was higher than71.43%in the control group,χ~2=4.941,P=0.026.The pregnancy rate was 80.95%,which was higher than the control group(59.52%),χ~2=4.613,P=0.032.The incidence of adverse reactions was 2.38%,which was lower than 19.05%in the control group.The difference was statistically significant,χ~2=4.480,P=0.014.CONCLUSION Low-dose bromocriptine combined with Xiaoy
作者
朱万丽
范迎丽
史昳香
ZHU Wan-li;FAN Ying-li;SHI Yi-xiang(Department of Gynaecology and Obstetrics,Ruyang County People's Hospital,Ruyang471200,P.R.China)
出处
《社区医学杂志》
2020年第5期349-352,共4页
Journal Of Community Medicine
关键词
溴隐亭
逍遥丸
高泌乳素血症性不孕症
血清泌乳素
bromocriptine
Xiaoyao pill
infertility due to hyperprolactinemia
serum prolactin
