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D变异型受血者产生同种抗-D合并抗-E及抗-C抗体1例 被引量:5

A case of recipient of D-variant type produced homologous anti-D combined with anti-E and anti-C antibodies
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摘要 1临床资料1.1病例资料患者,女,72岁,已婚,育有1子1女。20余年来反复出现胸闷气喘,有夜间阵发性呼吸困难,曾有风湿性心脏病、心功能不全病史,2002年在上海华山医院行二尖瓣金属置换术及主动脉瓣修复术。有脑梗死病史,甲亢病史1年,曾口服甲硫咪唑片治疗,目前停服,控制可,否认有高血压及其他慢性疾病,肝炎性肝硬化多年,2016年4月发现肝癌,在我院多次行肝癌介入治疗,目前合并肺转移。患者因受凉后出现咳嗽、胸闷情况. Accurate identification of Rh blood type,and accurately identify antibody type and specificity of anti-D,anti-E and anti-C,for patients to choose the appropriate donor,so as to ensure the safety of clinical blood transfusion.Identification of patient blood type by microcolumn gel method and saline test tube method,Rh-negative blood group confirmation test and absorption and release method were used to further determine the patient’s Rh blood group.The type and specificity of the antibody were determined by detecting the response pattern of patients’serum and spectral cells in the saline test tube method and the microcolumn gel method,meanwhile,antibody titer was determined.The patient was a D variant,IgG type anti-D,anti-E and anti-C antibodies were present in serum,and the titer was 256,4,8.In the work of blood type serology,we have to learn how to use it in a comprehensive way in different reaction conditions,to correctly identify the patient’s Rh blood type.It is also necessary to correctly select antibody screening and antibody specific identification cells to help us detect antibodies of clinical significance,avoid antibody omission and ensure the safety of clinical blood transfusion.
出处 《临床血液学杂志(输血与检验)》 CAS 2020年第1期140-142,147,共4页 Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
基金 江苏省科技厅2017年省科技发展计划项目(No:BE2017757).
关键词 D变异型 不规则抗体 抗-D 抗-E 抗-C D variant irregular antibody Anti-D Anti-E Anti-C
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