摘要
目的探讨地区HIV感染者HIV相关神经认知障碍患病率及临床特征。方法前瞻性收集2016年3月-2020年12月于我院就诊的601例HIV感染者的临床资料,参照HIV相关神经认知障碍的诊断标准诊断,分析地区HIV感染者HIV相关神经认知障碍患病率,收集地区HIV感染相关神经认知障碍患者的临床特征资料,同时纳入同期就诊的100例HIV阴性神经认知障碍患者临床特征资料,采用临近匹配法,匹配HIV感染者相关神经认知障碍与HIV阴性神经认知障碍患者,分析地区HIV感染者HIV相关神经认知障碍临床特征。结果纳入的的601例HIV感染者中剔除无效数据后最终纳入587例HIV感染者,地区HIV感染者HIV相关神经认知障碍患病率为30.83%(181/587),其中无症状神经认知障碍(ANI)、轻度神经认知功能障碍(MNI)、HIV相关痴呆(HAD)分别为62例(10.56%)、98例(16.70%)和21例(3.58%)。ANI和MNI占所有HIV相关神经认知障碍的88.40%。HIV感染者相关神经认知障碍与HIV阴性神经认知障碍患者最终共63对匹配成功;分别为HIV阳性组和HIV阴性组,比较两组患者临床特征显示HIV阳性组在学习记忆、工作记忆、信息处理速度、执行能力等多方面多量表得分明显低于HIV阴性组(P<0.05),运动能力、言语流利度两组间比较差异无统计学意义(P>0.05)。结论地区HIV感染者HIV相关神经认知障碍患病率为30.83%;ANI和MNI占所有HIV相关神经认知障碍的88.40%;且地区HIV感染者HIV相关神经认知障碍患者在学习记忆、工作记忆、信息处理速度、执行能力、睡眠等方面具更高功能障碍。
Objective To investigate the prevalence and clinical characteristics of HIV-related neurocognitive disorders in HIV-infected persons in the region.Methods Prospectively collect the clinical data of 601 HIV-infected patients who were treated in our hospital from March 2016 to December 2020,and diagnosed with reference to the diagnostic criteria for HIV-related neurocognitive disorders,and analyzed regional HIV-infected patients with HIV-related neurocognitive disorders.The disease rate,the clinical characteristics of patients with HIV infection-related neurocognitive impairment in the region were collected,and the clinical characteristics of 100 patients with HIV-negative neurocognitive impairment who visited the same period were included.The proximity matching method was used to match the neurocognitive impairment of HIV-infected patients.With HIV-negative neurocognitive impairment patients,the clinical characteristics of HIV-related neurocognitive impairment in HIV-infected patients in the region were analyzed.Results After excluding invalid data from the 601 HIV-infected patients,587 HIV-infected patients were finally included.The prevalence of HIV-related neurocognitive impairment among HIV-infected patients in the region was 30.83%(181/587),of which asymptomatic neurocognition There were 62 cases(10.56%),98 cases(16.70%)and 21 cases(3.58%)with cognitive impairment(ANI),mild neurocognitive dysfunction(MNI)and HIV-related dementia(HAD),respectively.ANI and MNI accounted for 88.40%of all HIV-related neurocognitive disorders.A total of 63 pairs of HIV-related neurocognitive disorders and HIV-negative neurocognitive disorders were finally matched successfully;they were HIV-positive and HIV-negative.Comparison of the clinical characteristics of the two groups showed that the HIV-positive group was better The multi-scale scores of information processing speed and execution ability were significantly lower than those of the HIV-negative group(P<0.05).There was no significant difference between the two groups in exerc
作者
李雅琪
陈彩玲
LI Yaqi;CHENG Cailing(Guyuan Center for Disease Control and Prevention,China 756000)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2021年第S01期8-10,共3页
Journal of Shenyang Pharmaceutical University
关键词
HIV
地区HIV感染者
神经认知障碍
患病率
临床特征
HIV
regional HIV-infected persons
neurocognitive impairment
prevalence
clinical features
