摘要
随着艾滋病母婴阻断项目的不断推进,新生儿艾滋病病毒(HIV)感染的发生风险逐渐降低,但全球HIV暴露新生儿的数量持续增加。巨细胞病毒(CMV)是HIV感染者重要的机会性感染病原体,能够加速HIV感染的疾病进程。同时,CMV也是宫内感染最常见的病毒,易引起新生儿出现严重的健康损害。目前对新生儿HIV暴露和CMV感染之间的关系了解较少,本文就HIV暴露新生儿中CMV感染的相关研究进展进行综合概述,为开展该人群的靶向干预和治疗提供参考。
With the expansion of the human immunodeficiency virus(HIV) prevention programs for mother-to-child transmission(PMTCT), the risk of HIV infection in neonates has gradually decreased. However, the number of HIV-exposed, uninfected infants is increasing. Cytomegalovirus(CMV), an important opportunistic pathogen in HIV-infected individuals, can accelerate the diseases progression of HIV. Meanwhile, it is the most common virus causing intrauterine infection and causes severe health problems to newborns. The relationship between neonatal HIV exposure and CMV infection has been poorly understood. This review is to comprehensively summarize the research progress on CMV infection among HIV-exposed uninfected infants and provide reference for the targeted intervention and treatment for this population.
作者
吴学福
刘振球
方绮雯
袁黄波
吴明山
张铁军
WU Xuefu;LIU Zhenqiu;FANG Qiwen;YUAN Huangbo;WU Mingshan;ZHANG Tiejun(Department of Epidemiology,School of Public Health,Fudan University,Key Laboratory of Public Health Safety(Fudan University),Ministry of Education,Shanghai 200032,China;State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development,School of Life Sciences,Fudan University,Shanghai 200438)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2020年第1期103-105,共3页
Chinese Journal of Aids & STD
基金
国家自然科学基金(81772170).
关键词
巨细胞病毒
艾滋病病毒
新生儿
cytomegalovirus
human immunodeficiency virus
infant
