摘要
过多能量摄入导致的肥胖已经成为了一个世界范围的问题,严重威胁着人们的健康。肥胖症以某些部位脂肪过度沉积为特点,而脂肪细胞的过度增殖和异常分化是肥胖发生的基础。越来越多的研究表明转录后调控在脂肪细胞分化过程中发挥着重要功能。STAU1(STAUFEN1)是一种双链RNA结合蛋白,能够靶向介导下游m RNA降解,参与脂肪细胞分化。STAU1可以在转录后水平调控脂肪细胞分化相关基因的可变剪接、翻译及降解,从而影响m RNA的代谢。该文就STAU1在脂肪细胞和组织中的功能和机制进行综述,希望为肥胖及2型糖尿病的治疗提供新的启示。
Obesity caused by excessive energy intake has become a worldwide problem,posing a serious threat to people’s health.Obesity is characterized by excessive deposition of fat in some parts,and the excessive proliferation and abnormal differentiation of fat cells are the basis of obesity.More and more studies have shown that posttranscriptional regulation plays an important role in adipocyte differentiation.STAU1(STAUFEN1)is a double-stranded RNA binding protein that can specifically mediate the degradation of target mRNA and participate in adipocyte differentiation.STAU1 can regulate the alternative splicing,translation and degradation of adipocyte differentiation related genes at the post transcriptional level,thereby affecting mRNA metabolism.This paper reviews the function and mechanism of STAU1 in adipocytes and tissues,hoping to provide new enlightenment for the treatment of obesity and type 2 diabetes.
作者
蒋硕
刘迪晖
孟轩羽
陈思远
梁小弟
JIANG Shuo;LIU Dihui;MENG Xuanyu;CHEN Siyuan;LIANG Xiaodi(School of Basic Medicine of Xinjiang Medical University,Urumqi 830011,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2022年第12期2402-2410,共9页
Chinese Journal of Cell Biology
基金
国家自然科学基金地区项目(批准号:81760162)
2017年度高校科研计划面上项目(批准号:XJEDU2017M016)
省部共建中亚高发病成因与防治国家重点实验室开放课题(批准号:SKL-HIDCA-2020-14)
新疆维吾尔自治区研究生科研创新项目(批准号:XJ2022G184)资助的课题
