摘要
目的分析新疆乌鲁木齐市新型冠状病毒肺炎(COVID-19)核酸检测复阳患者的临床特征。方法2020年9月至2021年10月,乌鲁木齐国际医院健康管理中心对本土742例COVID-19患者(2020年7~10月)进行随访,选取其中102例核酸检测复阳患者,收集临床资料进行回顾性分析。结果SARS-CoV-2复阳率13.75%。其中男性39例,女性63例,平均年龄36.89岁。首次住院分型:轻型20例,普通型64例,重型+危重型3例,无症状感染者15例。出院后至复阳平均19.04天。合并基础疾病:高血压病11例,糖尿病8例,冠心病4例,慢性支气管炎+哮喘4例,恶性肿瘤2例。实验室检查,血常规淋巴细胞计数及比例降低4例,其余生化指标无明显异常。恢复期胸部CT多表现为胸膜下磨玻璃渗出、胸膜下小结节、纤维索条、纤维灶,多在发病1-2个月后基本吸收。IgM抗体在出院2月后转阴,IgG抗体水平随出院时间的延长逐渐下降,至出院7月时稳定。复阳患者中,N基因单靶标阳性28例(27.4%)。复阳患者中相当一部分核酸检测间歇性阳性直至转阴。复阳患者共居人员随访期间未发现感染病例。结论复阳患者常合并基础疾病。核酸检测相当一部分为单靶标阳性,呈间隙性阳性直至转阴。IgG抗体水平较急性期未出现4倍及以上升高。胸部CT纤维化病灶多在发病后1-2月后吸收好转。复阳患者可能处于新冠病毒感染后恢复期,并不具有传染性。
Objective To analyze the clinical characteristics of patients with SARS-CoV-2(COVID-19)re-positive by nucleic acid detection in Urumqi of Xinjiang.Methods From September 2020 to October 2021,the Health Management Center of Urumqi International Hospital conducted a follow-up study on 742 local COVID-19 patients(from July to October 2020),and selected 102 of them who were re-positive by nucleic acid detection,and collected clinical data for retrospective analysis.Results The recovery rate of SARS-CoV-2 was 13.75%.There were 39 males and 63 females,with an average age of 36.89 years.The first hospitalization was divided into 20 cases of mild type,64 cases of ordinary type,3 cases of severe+critical type and 15 cases of asymptomatic infection.The average days from discharge to recuperation was 19.04 days.There were 11 cases of hypertension,8 cases of diabetes,4 cases of coronary heart disease,4 cases of chronic bronchitis combined with asthma,and 2 cases of malignant tumor.Laboratory tests showed that four patients had a decreased lymphocyte count and proportion,while no significant abnormalities were found in other biochemical indicators.On chest CT scans during the convalescence period,ground-glass opacities,small nodules,fibrous strands,and fibrous lesions were commonly seen,which were mostly absorbed within 1-2 months after the onset of the illness.IgM antibody was negative 2 months after discharge,while IgG antibody levels decreased gradually with the extension of the discharge time and stabilized at 7 months.Among the recurrent cases,28 cases(27.4%)were positive for the N gene single target.Among the recurrent cases,a considerable number of patients had intermittent positive nucleic acid tests until they turned negative.During the follow-up period for the co-habitants of recurrent cases,no infection cases were found.Conclusions Re-positive patients often have underlying medical conditions.A considerable part of the nucleic acid test were single target positive,and were gap positive until it turned negative.The
作者
寇文欣
李慧清
魏立华
王艳萍
闫蕤
王雁军
KOU Wenxin;LI Huiqing;WEI Lihua;WANG Yanping;YAN Rui;WANG Yanjun(Urumqi International Hospital,Urumqi,830099,China;Urumqi Midong District Traditional Chinese Medicine Hospital,Urumqi,830054,China;Urumqi Traditional Chinese Medicine Hospital,Urumqi,831400,China)
出处
《新疆医学》
2024年第6期639-642,共4页
Xinjiang Medical Journal
基金
乌鲁木齐市卫生健康委科技计划项目(项目编号:202137)
