摘要
目的探讨氯乙烯对男性职业人群肝功能和血清激素水平的影响。方法采用判断抽样方法,选择129名男性氯乙烯作业工人为接触组,以128名男性不接触职业病危害因素的行政办公人员对照组。对工作场所空气中氯乙烯时间加权平均浓度(CTWA)进行检测。对研究对象进行尿中亚硫基二乙酸(TDGA)水平、血常规、心电图和肝脏B型超声波检查,并检测其血清肝功能和性激素指标水平。结果接触组人群工作场所空气中氯乙烯CTWA中位数为0.90 mg/m3,几何均数为1.40 mg/m3。接触组人群尿中TDGA水平高于对照组(中位数:0.68 vs 0.02 mg/g肌酐,P<0.01)。接触组人群血红蛋白水平、红细胞计数、白细胞计数、红细胞压积、平均血小板体积、天冬氨酸氨基转移酶、总胆红素、间接胆红素和肝脏B型超声波的异常率均高于对照组(P<0.05)。与对照组比较,接触组人群血清催乳素、促黄体生成激素(LH)、促卵泡生成素和雌二醇水平均升高(P<0.05),催乳素、LH、雌二醇异常率均升高(P<0.05),睾酮水平下降(P<0.05)。与对照组比较,接触组TDGA低、中、高水平亚组人群血清催乳素水平均升高(P<0.05),异常率均升高(P<0.017)。结论氯乙烯可导致男性职业人群肝功能损伤,并具有生殖毒性。催乳素可作为氯乙烯生殖毒性的效应生物标志物。
Objective To explore the effect of vinyl chloride on the blood sex hormones and liver function of male workers. Methods A total of 129 male vinyl chloride workers(exposure group) and 128 male office workers who were not exposed to occupational hazards(control group) were selected as study subjects by judgment sampling method. The time weighted average concentration(CTWA) of vinyl chloride in the workplace air was measured. The level of urine thiodiglycolic acid(TDGA), blood routine, electrocardiogram and liver B-ultrasound were performed on the subjects. The serum levels of liver function and sex hormones were measured. Results The median of CTWA of vinyl chloride in the workplace was 0.90 mg/m3, and the geometric mean was 1.40 mg/m3. The level of urine TDGA in the exposed group was higher than that of the control group(median: 0.68 vs 0.02 mg/g Cr, P<0.01). The abnormal rate of hemoglobin level, erythrocyte count, leukocyte count, hematocrit, mean platelet volume, aspartate transaminase, total bilirubin, indirect bilirubin and liver B-ultrasound increased in the exposure group than that of the control group(P<0.05). The levels of serum prolactin, leuteinizing hormone(LH), follicle-stimulating hormone and estradiol in the exposure group increased, the abnormal rates of prolactin, LH and estradiol increased, and the level of testosterone decreased compared with the control group(P<0.05). The levels of prolactin in the low-, medium-and high-TDGA subgroups in the exposure group increased(P<0.05), and the abnormal rates increased compared with the control group(P<0.017). Conclusion Vinyl chloride can cause liver function damage in male workers and have reproductive toxicity. Prolactin can be used as a biomarker of reproductive toxicity of vinyl chloride.
作者
张桂云
刘楠
张晓星
薛玲
肖经纬
李斌
关维俊
ZHANG Guiyun;LIU Nan;ZHANG Xiaoxing;XUE Ling;XIAO Jingwei;LI Bin;GUAN Weijun(Tangshan Nanpu Development Zone Hospital,Tangshan,Hebei 063000,China;不详)
出处
《中国职业医学》
CAS
北大核心
2019年第6期684-688,共5页
China Occupational Medicine
基金
“十二五”国家科技支撑项目(2014BAI12B02).
关键词
氯乙烯
男性
工人
血清
肝功能
性激素
亚硫基二乙酸
Vinyl chloride
Men
Worker
Serum
Liver function
Sex hormones
Thiodiglycolic acid
