摘要
目的:考察姜黄素PVP-EPO固体分散体在大鼠体内的动力学。方法:采用高效液相色谱法测定大鼠血浆中姜黄素的浓度,比较灌胃给予原料药、PVP-EPO固体分散体后36h内的药动学特征。结果:姜黄素原料药、PVP-EPO固体分散体在大鼠体内的药动学参数Cmax分别是(45.8±5.6)ng/mL、(94.5±13.5)ng/mL,t1/2分别是(11.6±0.9)h、(9.5±2.7)h,AUC0~36h分别是(389.6±63.2)ng獉h/mL、(689.9±79.5)ng獉h/mL。与原料药相比,PVP-EPO固体分散体的相对生物利用度为177.1%。结论:PVP-EPO固体分散体的生物利用度明显高于原料药。
Objective:To investigate the pharmacokinetics of Curcumin-PVP-EPO solid dispersion in rats.Methods:The concentration of curcumin in rat plasma was determined by high performance liquid chromatography(HPLC),and the pharmacokinetic characteristics of curcumin within 36 hours after intragastric administration of raw material drug and solid dispersion were compared.Results:The pharmacokinetic parameters of curcumin raw materials and solid dispersion in rats were calculated as follows:Cmax were(45.8±5.6)ng/mL and(94.5±13.5)ng/mL respectively,t1/2 were(11.6±0.9)h and(5±2.7)h respectively;AUC0~36 h were(389.6±63.2)ng·h/mL and(689.9±79.5)ng·h/mL respectively.Compared with curcumin raw,the relative bioavailability of solid dispersion was 177.1%.Conclusion:The bioavailability of Curcumin-PVP-EPO solid dispersion was significantly higher than that of API.
作者
尹丽
张纯刚
周旖璇
张强
程岚
Yin Li;Zhang Chungang;Zhou Yixuan;Zhang Qiang;Cheng Lan(College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 116620,China)
出处
《亚太传统医药》
2021年第5期14-18,共5页
Asia-Pacific Traditional Medicine
基金
国家自然科学基金(81503257)
国家重点研发计划(2018YFC1706903)
辽宁省博士启动基金(201501098)
辽宁省自然科学基金指导计划(2019-ZD-0968)
中医脏象理论及应用国家教育部重点实验室一般项目(zyzx1809)
