摘要
探讨不同剂量右美托咪定联合罗哌卡因腹横肌平面阻滞在腹腔镜输卵管切除术后的镇痛效果。将2017年6至2019年6于该院行腹腔镜输卵管切除术治疗的172例患者作为观察对象,均于术毕开展超声引导腹横肌平面阻滞。依据随机数表法分成对照组、研究A组、研究B组、研究C组,各43例。腹横肌平面阻滞过程中,对照组给予0.9%氯化钠注射液、0.375%罗哌卡因,研究A组给予0.25 g/kg右美托咪定、0.375%罗哌卡因,研究B组给予0.5 g/kg右美托咪定、0.375%罗哌卡因,研究C组给予1.0 g/kg右美托咪定、0.375%罗哌卡因。观察4组患者术后4,8,12,24 h镇痛效果、镇静效果和不良反应。研究A组、研究B组、研究C组患者术后4,8,12,24 h的疼痛VAS评分均低于对照组,且研究B组、研究C组低于研究A组(P<0.05);4组患者术后4,8,12,24 h的Ramsay镇静评分差异无统计学意义(P>0.05);研究A组患者术后不良反应总发生率略高于对照组,但差异无统计学意义(P>0.05);研究B组、研究C组患者术后不良反应总发生率均高于对照组、研究A组(P<0.05);研究C组患者术后不良反应总发生率高于研究B组,差异有统计学意义(P<0.05)。结果显示0.5 g/kg右美托咪定联合罗哌卡因腹横肌平面阻滞能增强腹腔镜输卵管切除术后患者镇痛及镇静效果。
To investigate the analgesic effect of different doses of dexmedetomidine combined with ropivacaine for transverse abdominis muscle block after laparoscopic salpingectomy,172 cases of patients underwent laparoscopic salpingectomy from June 2017 to June 2019 were enrolled in this study.All the patients were given ultrasound-guided abdo transverse plane block at the end of surgery,and the patients were divided into control group,study group A,study group B,and study group C based on the random number table method,with 43 cases in each group.During the plane block of the transverse abdominis,the patients in the control group were given0.9%sodium chloride injection and 0.375%ropivacaine for postoperative analgesia.The patients in group A were given 0.25 mg/kg dexmedetomidine and 0.375%ropivacaine for postoperative analgesia.The patients in group B were given 0.5 mg/kg dexmedetomidine and 0.375%ropivacaine for postoperative analgesia.The patients in group C were given 1.0 mg/kg dexmedetomidine and 0.375%ropivacaine for postoperative analgesia.The analgesic effect,sedative effect and incidence of adverse reactions were observed at 4,8,12 and 24 h after operation in the four groups.The pain VAS scores of group A,study group B and study group C were lower than those of the control group at 4,8,12 and 24 h after operation,and the study group B and study group C were lower than the study group A(P<0.05).There were no significant differences in the Ramsay sedation scores between the four groups at 4,8,12 and 24 h after operation(P>0.05).The total incidence of postoperative adverse reactions in group A patients was slightly higher than that in the control group,but the difference was not statistically significant(P>0.05).The total incidence of postoperative adverse reactions in group B and group C was higher than that in control group and study group A(P<0.05).The total incidence of postoperative adverse reactions in group C patients was higher than that in group B(P<0.05).The result showed 0.5 mg/kg dexmedetomidine combined
作者
赵丽
吴艳琴
林丽娜
ZHAO Li;WU Yan-qin;LIN Li-na(Department of Anesthesiology,Wenzhou Third Clinical School(Wenzhou People's Hospital),Wenzhou Medical University,Wenzhou 325000,China;Department of Anesthesiology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,China)
出处
《药物生物技术》
CAS
2020年第5期420-423,共4页
Pharmaceutical Biotechnology
基金
浙江省医药卫生科技计划项目(No.2017KY147)
关键词
右美托咪定
罗哌卡因
腹横肌平面阻滞
腹腔镜输卵管切除术
镇痛效果
不良反应
Dexmedetomidine
Ropivacaine
Transversal abdominal muscle block
Laparoscopic salpingectomy
Analgesic effect
Adverse effects
