摘要
目的建立邻氯苯基环戊酮及合成工艺中的10种相关化合物的定性检验方法及邻氯苯基环戊酮的定量检验方法。方法样品经液液提取,通过气相色谱-质谱法(GC-MS)进行定性检验,通过气相色谱法(GC-MS)进行单点外标法、外标工作曲线法定量检验。结果通过实验,确定检验样品中的提取溶剂、提取方式、分析条件等参数,10种物质得到快速筛选、准确定性;邻氯苯基环戊酮在一定浓度范围线性关系良好。结论本方法简单、快速、灵敏度高、避免样品分解,适用于制毒现场检材的10种目标物质的检测。
Objective To establish the qualitative test method of 10 related substances in the synthesis of o-Chlorophenyl cyclopentyl ketone scene and the quantitative test method of o-Chlorophenyl cyclopentyl ketone.Methods The samples were extracted by liquid-liquid,qualitative analyzed by gas chromatography-mass spectrometry(GC-MS),quantitative analyzed by single point external standard method and external standard working curve method of gas chromatography(GC-MS).Results Through experiments,the extraction solvent,extraction method,analysis conditions and other parameters were determined.The 10 substances were screened quickly and identified accurately.o-Chlorophenyl cyclopentyl ketone showed a good linear relationship in a certain concentration range.Conclusion The method is simple,rapid,sensitive and avoids sample decomposition.It is suitable for the detection of 10 target substances in the on-site samples of drug production.
作者
张荣华
刘茂兴
曹苏明
刘晓辉
于洪沙
陈军
郑珲
ZHANG Rong-hua;LIU Mao-xing;CAO Su-ming;LIU Xiao-hui;YU Hong-sha;CHEN Jun;ZHENG Hui(Daqing Public Security Bureau of Heilongjiang Province,Daqing 163311,Heilongjiang,China;Key Laboratory of Drug Monitoring and Control,Drug Intelligence and Forensic Center,Ministry of Public Security,P.R.C.,Beijing 100193,China)
出处
《中国药物依赖性杂志》
CAS
CSCD
2023年第4期266-270,共5页
Chinese Journal of Drug Dependence
基金
国家重点研发计划国家质量基础设施体系专项课题(2021YFF0602501)
