摘要
目的:采用荟萃分析(Meta分析)方法,系统评价中西医结合治疗直肠癌术后肠麻痹的有效性与安全性。方法:检索中国知网、PubMed、维普数据库、中国生物医学文献数据库和万方等数据库,搜索公开发表的中西医结合治疗直肠癌术后肠麻痹的随机对照试验(观察组患者采用中西医结合治疗,对照组患者单纯采用西医常规治疗),提取资料并评价文献质量后,采用Rev Man5.3软件进行Meta分析。结果:共纳入6篇文献,涉及528例患者。Meta分析结果显示,治疗后,观察组患者的治疗有效率明显高于对照组(RR=1.22,95%CI=1.13~1.32,P<0.00001),中医证候积分明显低于对照组(MD=-1.15,95%CI=-1.24^-1.06,P<0.00001),肠鸣音恢复时间(MD=-16.59,95%CI=-19.05^-14.14,P<0.00001)、排气恢复时间(MD=-12.30,95%CI=-13.07^-11.52,P<0.00001)、排便恢复时间(MD=-14.17,95%CI=-17.17^-11.18,P<0.00001)和腹胀消失时间(MD=-1.13,95%CI=-2.07^-0.19,P=0.02)明显短于对照组,差异均有统计学意义;观察组患者的胃肠减压消失时间短于对照组,但差异无统计学意义(MD=-0.17,95%CI=-1.83^-1.49,P=0.84)。治疗期间,患者无明显不良反应发生。结论:相对于单纯西医常规治疗,中西医结合治疗直肠癌术后肠麻痹具有更好的疗效。鉴于本研究存在的局限性,期待更多高质量、高水平的临床随机对照试验提供更严谨、可靠的数据。
OBJECTIVE:To systematically evaluate the clinical efficacy and safety of combined traditional Chinese and western medicine in the treatment of postoperative enteroparalysis of recal cancer based on Meta-analysis.METHODS:CNKI,PubMed,VIP database,CBM and Wanfang database were retrieved to collect the clinical randomized controlled trial(RCT)of combined traditional Chinese and western medicine in the treatment of postoperative enteroparalysis of recal cancer(the observation group was treated with combined traditional Chinese and western medicine,while the control group received western medicine).After the data were extracted and the quality of the included literature was evaluated,Meta-analysis was conducted by RevMan 5.3 software.RESULTS:Totally 6 literature were collected,including 528 patients.Meta analysis results showed that the total efficiency of the observation group was significantly higher than that of the control group(RR=1.22,95%CI=1.13-1.32,P<0.00001),and the TCM symptom score was significantly lower than that of the control group(MD=-1.15,95%CI=-1.24--1.06,P<0.00001),bowel sound recovery time(MD=-16.59,95%CI=-19.05--14.14,P<0.00001),recovery time of exhaust(MD=-12.30,95%CI=-13.07--11.52,P<0.00001),recovery time of defecation(MD=-14.17,95%CI=-17.17--11.18,P<0.00001)and disappearance time of abdominal distension(MD=-1.13,95%CI=-2.07--0.19,P=0.02)were significantly shorter than those of the control group,with statistically significant differences.The disappearance time of gastrointestinal decompression in the observation group was shorter than that in the control group,but the difference was not statistically significant(MD=-0.17,95%CI=-1.83--1.49,P=0.84).During the treatment,no obvious adverse drug reactions occurred in both groups.CONCLUSIONS:Compared with conventional western medicine,combined traditional Chinese and western medicine has a better curative effect on postoperative enteroparalysis of rectal cancer.In view of the limitations of this study,more high-quality,high-level randomized controlled
作者
胡启超
屈彩艳
曾进浩
郭耀光
胡纪可
李聪
马骁
HU Qichao;QU Caiyan;ZENG Jinhao;GUO Yaoguang;HU Jike;LI Cong;MA Xiao(School of Pharmacy,Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine,Chengdu University of Traditional Chinese Medicine,Sichuan Chengdu 611137,China;School of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Sichuan Chengdu 611137,China)
出处
《中国医院用药评价与分析》
2020年第2期144-148,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家自然科学基金项目(No.81703725)
四川省科技厅应用基础项目(No.2019YJ0492)
成都中医药大学教改建设项目(JGZD201918)
成都中医药大学杏林学者学科人才科研提升计划(No.QNXZ2018025).
关键词
中西医结合治疗
直肠癌术后肠麻痹
META分析
Combined traditional Chinese and western medicine
Postoperative enteroparalysis of recal cancer
Meta-analysis
