摘要
目的探讨miRNA-451表达与胃癌患者预后相关性,为临床治疗提供参考。方法选取漯河市第二人民医院2015年1月—2017年1月收治的行胃癌根治术的90例患者进行研究,根据患者miRNA-451中位表达水平分为低表达组(34例)和高表达组(56例)。对mi-RNA表达与胃癌患者临床病理特征进行单因素分析与多因素分析,并以Kaplan-Meier生存曲线分析癌组织中miRNA-451高、低表达患者生存的差异。结果不同TNM分期、不同分化程度及不同转移情况间,miRNA-451的表达差异有统计学意义(P<0.05)。TNM分期(OR=6.3,95%CI 2.9~9.5)及淋巴结转移(OR=7.5,95%CI 3.8~11.0)为胃癌组织中miRNA-451表达的独立性影响因素(P<0.05)。低表达组中位生存时间为(12.79±3.81)个月(95%CI 8.33~23.78);高表达组中位生存时间为(20.72±5.93)个月(95CI%16.33~32.08),两组相比Log-Rank值为8.53(P=0.003)。结论miRNA-451表达与胃癌患者TNM分期及淋巴结转移相关,且与患者预后密切相关。
Objective To investigate the relationship between miRNA-451 expression and prognosis in patients with gastric cancer,and to provide reference for clinical treatment.Methods Ninety patients undergoing radical gastrectomy in the Second People’s Hospital of Luohe City from January 2015 to January 2017 were enrolled.The patients were divided into low expression group(34 cases)and high expression group(56 cases)according to the median expression level of miRNA-451.Univariate analysis and multivariate analysis were performed on the expression of mi-RNA and clinicopathological features of gastric cancer patients.The Kaplan-Meier survival curve was used to analyze the difference of survival time in patients with high and low expression of miRNA-451 in cancer tissues.Results There were significant differences in the expression of miRNA-451 between different TNM stages,different degrees of differentiation and different metastasis(P<0.05).TNM stage(OR=6.3,95%CI 2.9-9.5)and lymph node metastasis(OR=7.5,95%CI 3.8-11.0)were independent factors affecting the expression of miRNA-451 in gastric cancer tissues(P<0.05).The median survival time of the low expression group was(12.79±3.81)months(95%CI 8.33-23.78);the median survival time of the high expression group was(20.72±5.93)months(95%CI 16.33-32.08).The log-rank value of the two groups was 8.53(P=0.003).Conclusion The expression of miRNA-451 is associated with TNM stage and lymph node metastasis in patients with gastric cancer,and it is closely related to the prognosis of patients.
作者
李静
LI Jing(Department of Pathology,the Second People's Hospital of Luohe City,Luohe,Henan 462000,China)
出处
《慢性病学杂志》
2020年第7期974-976,共3页
Chronic Pathematology Journal
