Insulin reverses MCP-1 suppressed cholesterol efflux to HDL3/ApoA1 through up-regulation of ABCA1,ABCG1 and SR-BI in differentiated 3T3-L1 adipocytes

Insulin reverses MCP-1 suppressed cholesterol efflux to HDL3/ApoA1 through up-regulation of ABCA1,ABCG1 and SR-BI in differentiated 3T3-L1 adipocytes

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摘要 Objective Insulin has been reported to influence cholesterol removal from different cells,but the Results have been controversial.Based on our previous study,which we found that insulin promote cholesterol efflux from HepG2 cells and can reverse the decreased cholesterol efflux to HDL though PI3K-Akt pathway,we further investigate the effects of insulin on damaged cholesterol efflux by MCP-1 in this report.

作者 Runlu Sun Canxia Huang Jinlan Bao Jieyu Jiang Yuling Zhang

机构地区 Sun Yat-sen Memorial Hospital The Sixth Affiliated Hospital

出处《中国循环杂志》 CSCD 北大核心 2018年第S01期120-121,共2页 Chinese Circulation Journal

关键词 MCP-1 HDL3/ApoA1 PI3K-AKT

分类号 R587.1 [医药卫生—内分泌]

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中国循环杂志

2018年第S01期

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Insulin reverses MCP-1 suppressed cholesterol efflux to HDL3/ApoA1 through up-regulation of ABCA1,ABCG1 and SR-BI in differentiated 3T3-L1 adipocytes

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