SB525334 attenuates MCT-induced pulmonary arterial hypertension in rats

SB525334 attenuates MCT-induced pulmonary arterial hypertension in rats

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摘要 Background and Objective Pulmonary arterial hypertension(PAH)is a pathophysiological disorder characterized by increased pulmonary arterial pressure and pulmonary vascular remodeling,its mechanism remains unclear.Transforming growth factor-β(TGF-β)family plays a pivotal role in pulmonary arterial hypertension.SB525334 is a selective inhibitor of TGF-βreceptor 1,this study aimed to investigate the effects of SB525334 on the alleviation of monocrotalineinduced pulmonary hypertension.

作者 Qi Jin Qin Luo Zhihui Zhao Xue Yu Lu Yan Zhihong Liu

机构地区 Pulmonary Vascular Disease Center

出处《中国循环杂志》 CSCD 北大核心 2018年第S01期168-169,共2页 Chinese Circulation Journal

关键词 PULMONARY ARTERIAL HYPERTENSION TGF-Β SB525334

分类号 R544.1 [医药卫生—心血管疾病] R-332 [医药卫生—内科学]

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中国循环杂志

2018年第S01期

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SB525334 attenuates MCT-induced pulmonary arterial hypertension in rats

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