摘要
结直肠癌是一种常见的恶性肿瘤,而结直肠癌肝转移是导致患者死亡的主要原因之一,目前的治疗对结直肠癌肝转移仍十分有限。肿瘤转移是一个多基因、多步骤的过程,多种信号通路如Wnt/β-catenin、HGF/c-MET、PI3K/Akt/mTOR、RAS-ERK、TGF-β/SMAD等及相关基因均参与了结直肠癌肝转移的发生,靶向相关通路或基因的治疗可能可以减少患者的死亡率。已有研究证实,上皮—间充质转化是肿瘤发生转移的重要步骤之一,而上述多种信号通路均在此过程中发挥作用。全文就与结直肠癌肝转移相关的多种信号通路研究进展进行综述,以期为找到新型抗癌药物的潜在靶点提供依据。
Colorectal cancer(CRC)is a common malignant tumor.And colorectal cancer liver metastasis(CRCLM)is one of the main causes of death for CRC patients.But there is no effective treatment for this metastasis process.Tumor metastasis is a polygenic and multi-steps process.Various signaling pathways,such as Wnt/β-catenin,HGF/c-MET,PI3K/Akt/mTOR,RAS-ERK,TGF-β/SMAD and related genes are involved in the occurrence of CRCLM.Targeting these signaling pathways orgenes may reduce mortality of patients.Studies have confirmed that epithelial-to-mesenchymal transition is one of the most important steps of tumor metastasis,and all the signaling pathways discussed previously play a role in this progression process.In this article,the current researches of signaling pathways related to colorectal cancer liver metastasis are reviewed in order to provide evidence to find the potential targets of new anticancer drugs.
作者
包莹
曹培国
BAO Ying;CAO Pei-guo(The Third Xiangya Hospital of Central South University,Changsha 410013,China)
出处
《中国肿瘤》
CAS
CSCD
北大核心
2020年第2期134-139,共6页
China Cancer
关键词
结直肠癌
肝转移
信号通路
基因
上皮—间充质转化
colorectal cancer
liver metastasis
signaling pathway
gene
epithelial-to-mesenchymal transition
