摘要
目的探讨血管紧张素受体拮抗剂和醛固酮拮抗剂螺内酯对慢性心力衰竭治疗效果。方法选取我院收治的慢性心力衰竭患者100例,随机均分两组,各50例。对照组在常规治疗基础上使用血管紧张素受体拮抗剂(ARB)治疗,试验组在常规治疗基础上使用醛固酮拮抗剂螺内酯治疗,比较两组治疗前后各项临床指标(舒张压、收缩压、心率及LVEF)、治疗效果以及不良反应(行走不协调、水电解质紊乱、过敏、头痛、恶心呕吐)发生率等。结果两组治疗后临床指标(舒张压、收缩压、心率及LVEF)改善效果及临床治疗效果、不良反应发生率比较差异均无统计学意义(P>0.05)。结论血管紧张素受体拮抗剂和醛固酮拮抗剂螺内酯均对慢性心力衰竭患者具有较好的临床治疗效果,均能有效改善心功能,促进症状缓解,且不良反应较少,预后效果理想,且两种药物治疗效果无差异,均具有良好的临床应用价值。
Objective To explore the therapeutic effects of angiotensin receptor blocker(ARB)and aldosterone antagonist spironolactone for chronic heart failure.Methods One hundred patients with chronic heart failure admitted to our hospital were selected and randomly divided into two groups:study group,control group,50 cases in each.The control group was treated with angiotensin receptor blocker,and the study group was treated with aldosterone antagonist spironolactone on the basis of routine treatment.The clinical indicators(diastolic pressure,systolic pressure,heart rate and LVEF),treatment effects and incidence of adverse reactions(uncoordinated walking,fluid and electrolyte imbalance,allergy,headache,nausea and vomiting)were compared between the two groups before and after treatment.Results There was no significant difference in clinical index(diastolic blood pressure,systolic blood pressure,heart rate and LVEF)improvement effect,clinical treatment effect,and incidence of adverse reactions between the two groups after treatment(P>0.05).Conclusion There are good therapeutic effect of angiotensin receptor blocker and aldosterone antagonist spironolactone for chronic heart failure,and can effectively improve the cardiac function of patients,promote symptom relief,with few adverse reactions and a good prognosis;there is no significant difference between the two drugs,and both have good clinical application value.
作者
靳婷婷
王凯
JIN Ting-ting;WANG Kai(Tianjin Hospital International Treatment Centre,Tianjin 300200,China)
出处
《中国误诊学杂志》
CAS
2021年第4期289-291,共3页
Chinese Journal of Misdiagnostics
