摘要
[目的]探索新辅助化疗在中晚期低位直肠癌患者中的临床效果。[方法]选取2016-10—2018-10接受治疗的90例中晚期低位直肠癌患者为研究对象,按照随机数字表法分为2组,对照组44例,应用直肠低位前切除术治疗;观察组46例,在对照组基础上添加新辅助化疗。采用实体瘤临床疗效评价标准对患者的临床疗效进行评估,比较2组患者治疗前后的肿瘤标志物水平,统计2组患者手术相关指标以及术后并发症的发生情况。[结果]对照组7例完全缓解,11例部分缓解,8例疾病稳定;观察组9例完全缓解,15例部分缓解,11例疾病稳定;观察组临床疗效总有效率明显高于对照组(P<0.05)。治疗后,2组患者的CEA、VEGF、CA242及CA724水平均下降,观察组的CEA、VEGF、CA242及CA724水平明显低于对照组,差异有统计学意义(P<0.05)。2组患者手术时间、术中出血量数据对比差异无统计学意义(P>0.05)。观察组术后排气时间、进食时间显著低于对照组(P<0.05)。对照组共发现6例切口感染,3例吻合口瘘,2例肠梗阻,3例吻合口出血;观察组共发现2例切口感染,1例吻合口瘘,1例肠梗阻,1例吻合口出血;观察组术后并发症总发生率显著低于对照组(P<0.05)。[结论]新辅助化疗在中晚期低位直肠癌患者中的疗效较好,能够降低肿瘤标志物水平,且患者术后排气时间和进食时间均有明显改善,术后并发症较少,适合临床推广应用。
[Objective]To explore the clinical effects of neoadjuvant chemotherapy in the treatment of patients with advanced rectal cancer.[Methods]Ninety patients with advanced low rectal cancer who were treated in our hospital from October 2016 to October 2018 were enrolled in the study.They were divided into 2 groups according to the random number table method.The control group was treated with conventional surgery and the observation group was in the control group.Add neoadjuvant chemotherapy based on it.The clinical efficacy of the patients was evaluated by the clinical evaluation criteria of solid tumors.Comparing the tumor marker levels before and after treatment in the two groups of patients,The surgical related indexes and postoperative complications were compared between the two groups.[Results]A total of 7 cases of CR,11 cases of PR,and 8 cases of SD were found in the control group.9 cases of CR,15 cases of PR,and 11 cases of SD were found in the observation group.The total effective rate of the observation group was significantly higher than that of the control group.The data comparison was statistically significant(P<0.05).After treatment,the levels of CEA,VEGF,CA242 and CA724 in the two groups were decreased,and the levels of CEA,VEGF,CA242 and CA724 in the treated patients were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the operation time and intraoperative blood loss between the two groups(P>0.05).The postoperative exhaust time and postoperative feeding time of the observation group were significantly lower than the postoperative exhaust time and postoperative feeding time.The data comparison was statistically significant(P<0.05).In the control group,6 cases of wound infection were found,3 cases of anastomotic leakage,2 cases of intestinal obstruction,and 3 cases of anastomotic bleeding.Two cases of incisional infection were found in the observation group,1 case of anastomotic leakage,1 case of intestinal obstruction,and 1 case of anastomo
作者
高树全
薛军
张迎春
崔大鹏
范露露
刘振显
GAO Shu-quan;XUE Jun;ZHANG Ying-chun;CUI Da-peng;FAN Lu-lu;LIU Zhen-xian(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)
出处
《中国中西医结合消化杂志》
CAS
2020年第3期215-218,226,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
河北省卫生厅科研基金(No:20180813).
关键词
新辅助化疗
中晚期低位直肠癌
临床疗效
neoadjuvant chemotherapy
middle and late stage low rectal cancer
clinical efficacy
