摘要
目的:研究木瓜Chaenomeles sinensis(Thouin)Koehne中的倍半萜类化学成分。方法:采用Diaion HP-20、Toyopearl HW-40、MCI Gel CHP-20、ODS、硅胶等柱填料并结合半制备液相等柱色谱技术对木瓜提取物的化学成分进行分离,并经波谱数据分析鉴定化合物的结构。结果:从木瓜中分离得到9个倍半萜类化合物,分别鉴定为:2-反式-4-反式-脱落酸(1)、(±)-abscisin methyl ester(2)、(+)-dehydrovomifoliol(3)、blumenol A(4)、blumenol C glucoside(5)、(6S,9R)-roseoside(6)、dihydrophaseic acid(7)、(+)-isololiolide(8)、(3R,6S)-3-hydroxy-2,2,6-trimeth-7-oxabicyclo[4.3.0]non-9-en-8-one(9)。结论:化合物1~9均为首次从该植物中分离得到。
Objective:To study the sesquiterpenes from the fruits of Chaenomeles sinensis.Methods:The compounds from the extract of the fruits of Chaenomeles sinensis were isolated by chromatographic methods,including Diaion HP-20,Toyopearl HW-40,MCI gel CHP-20,ODS silica gel chromatography and semi-preparative-HPLC.The structures of the compounds were identified by spectral data analysis.Results:Nine sesquiterpenes were isolated from the fruits of Chaenomeles sinensis and identified as 2-trans-4-trans-abscisic acid(1),(±)-abscisin methyl ester(2),(+)-dehydrovomifoliol(3),blumenol A(4),blumenol C glucoside(5),(6S,9R)-roseoside(6),dihydrophaseic acid(7),(+)-isololiolide(8),(3R,6S)-3-hydroxy-2,2,6-trimeth-7-oxabicyclo[4.3.0]non-9-en-8-one(9),respectively.Conclusion:Compounds 1 to 9 are isolated from the fruits of Chaenomeles sinensis for the first time.
作者
李孟
张志广
石静亚
张靖柯
郑晓珂
冯卫生
LI Meng;ZHANG Zhi-guang;SHI Jing-ya;ZHANG Jing-ke;ZHENG Xiao-ke;FENG Wei-sheng(Henan University of Chinese Medicine,Zhengzhou 450046,China;The Engineering and Technology Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China;College of Pharmacy,Minzu University of China,Beijing 100081,China)
出处
《中药材》
CAS
北大核心
2021年第3期600-603,共4页
Journal of Chinese Medicinal Materials
基金
中央引导地方科技发展专项(豫财科[2016]149号)
国家重点研发计划-中医药现代化研究重点专项(2017YFC1702800)
国家重点研发计划(2019YFC1708802)
关键词
光皮木瓜
提取分离
化学成分
倍半萜类
Chaenomeles sinensis(Thouin)Koehne
Extraction and isolation
Chemical constituents
Sesquiterpenes
