摘要
目的评估三联疗法治疗儿童白癜风的疗效及安全性。方法收集2012年1月至2018年12月在吉林大学第一医院经过三联疗法并持续治疗1年以上的儿童白癜风患者的病例资料。整理并总结临床数据,评估其疗效及安全性。结果一共纳入50例患儿,男20例,女30例,平均年龄(7.2±3.0)岁,中位病程4个月,受累面积均<5%,进展期50例,中位疗程18个月。总体有效率、显效率和治愈率分别为90.0%,66.0%和16.0%。节段型中累及头面颈部比例最高,非节段型中累及躯干比例最高。非节段型中累及躯干、四肢及肢端的比例明显高于节段型,差异有统计学意义(χ^(2)=4.388,χ^(2)=3.951,χ^(2)=9.375,P<0.05)。节段型与非节段型病例的疗效无统计学差异。结论针对儿童白癜风的特点,抓住治疗时机,给予三联疗法持续长期治疗安全有效,可有效控制病情。
Objective To evaluate the efficacy and safety of TCI and NB-UVB combined SC therapy in pediatric vitiligo patients.Methods Pediatric vitiligo patients treated with TCI and NB-UVB combined SC therapy visited at our department were retrospectively collected.Clinical data and treatment effectiveness were summarized,and factors influencing the therapeutic effect were further analyzed.Results A total of 50children with vitiligo were enrolled in this study.There were 30 female and 20 male,mean age(7.2±3.0)years,median duration of vitiligo 4 months;50 activity status,median duration of treatment 18 months.The overall>25%,>50%,and>90%repigmentation rates were 90.0%,66.0%and 16.0%,respectively.The proportion of head,face and neck involved in segmental type was the highest,while the proportion of trunk involved in non-segmental type was the highest.The proportion of trunk,limbs,and extremities involved in non-segmental type was significantly higher than that in segmental type,and the difference was statistically significant(χ^(2)=4.388,χ^(2)=3.951,χ^(2)=9.375,P<0.05).Conclusion TCI and NB-UVB combined SC therapy is safe and effective.
作者
刘媛媛
姚蕾
李珊山
LIU Yuanyuan;YAO Lei;LI Shanshan(Department of Dermatology and Venerology,First Hospital of Jilin University,Changchun 130021,China)
出处
《皮肤科学通报》
2022年第4期306-311,5,共7页
Dermatology Bulletin
