摘要
目的:探讨柳氮磺胺吡啶联合中药灌肠治疗溃疡性结肠炎的临床疗效。方法:选取2016年8月—2018年8月我院收治的溃疡性结肠炎患者60例,按随机数字表法分为两组,各30例。联合治疗组采用柳氮磺胺吡啶联合中药灌肠治疗,单独治疗组采用柳氮磺胺吡啶治疗。比较两组血清白细胞介素(IL)-2、C反应蛋白(CRP)、尿乳果糖/甘露醇比值(L/M)、Sutherland指数、临床疗效。结果:联合治疗组总有效率、血清IL-2水平高于单独治疗组,血清CRP水平、L/M、Sutherland指数低于单独治疗组,差异有统计学意义(P<0.05)。结论:溃疡性结肠炎柳氮磺胺吡啶联合中药灌肠治疗的临床疗效较柳氮磺胺吡啶单独治疗显著。
Objective:To explore the clinical efficacy of sulfasalazine combined with traditional Chinese medicine enema in the treatment of ulcerative colitis.Methods:60 patients with ulcerative colitis admitted to our hospital from August 2016 to August 2018 were selected and randomly divided into two groups:a combined treatment group and a single treatment group,30 cases each.The patients in the combined treatment group were treated with sulfasalazine combined with traditional Chinese medicine enema,and the patients in the single treatment group were treated with sulfasalazine.The levels of serum interleukin(IL)-2 and C-reactive protein(CRP),the ratio of urine lactulose/mannitol(L/M),Sutherland index and clinical efficacy were compared between the two groups.Results:The total effective rate and the level of serum IL-2 in the combined treatment group were higher than those in the single treatment group(P<0.05).Conclusion:Sulfasalazine combined with traditional Chinese medicine enema is more effective than sulfasalazine alone in the treatment of ulcerative colitis.
作者
张磊
王会丽
Zhang Lei;Wang Hui-li(DepartmentⅢof Internal Medicine,Zhengzhou Ruixiang Hospital,Zhengzhou Henan 450100,China;Xingyang People’s Hospital,Zhengzhou Henan 450100,China)
出处
《中国合理用药探索》
CAS
2019年第11期163-165,共3页
Chinese Journal of Rational Drug Use
关键词
柳氮磺胺吡啶
中药灌肠
溃疡性结肠炎
Sulfasalazine
Traditional Chinese Medicine Enema
Ulcerative Colitis
